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Peptide record

TPDB72480

Neurotoxin standard
67 amino acids
Basic Information
3D PDB MODEL
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TPDB72480
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 67-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MRCFPVFIILLLLIASAPCFDARTKTDDDVPLSSLRDNLKRTIRTRLNIRECCEDGWCCTAAPLTGR
Physicochemical Analysis
C329H542N96O95S7
QHY
L
7586.93
8.02
10
8
26
+2
9.56
0.088
97.61
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
77.44
17
Residue Composition
number
5
A
8
R
2
N
6
D
6
C
2
E
0
Q
2
G
0
H
5
I
9
L
2
K
1
M
3
F
4
P
3
S
6
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 8 N: 2 D: 6 C: 6 E: 2 Q: 0 G: 2 H: 0 I: 5 L: 9 K: 2 M: 1 F: 3 P: 4 S: 3 T: 6 W: 1 Y: 0 V: 2
Chemical Descriptors
67
C329H542N96O95S7
7586.93
8.02
+2
9.56
0.088
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish. {ECO:0000269|PubMed:10318957}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus textile (Cloth-of-gold cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice.
Epsilon-conotoxin TxVA (Epsilon-TxIX) (Tx-012) (Tx5.2) (tx5a)
cone snail
Conotoxin T superfamily
Evidence at protein level
3D-structure Bromination Calcium channel impairing toxin Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Glycoprotein Hydroxylation Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10521453}.
Additional Detail Fields 7 fields
3D-structure Bromination Calcium channel impairing toxin Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Glycoprotein Hydroxylation Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Signal Toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin T superfamily
Epsilon-conotoxin TxVA (Epsilon-TxIX) (Tx-012) (Tx5.2) (tx5a)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10521453}.
cone snail