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Peptide record

TPDB72474

Neurotoxin standard
93 amino acids
Basic Information
3D PDB MODEL
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TPDB72474
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 93-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MMSKMGAMFVLLLLFTLASSQQEGDVQARKTHPKREFQRILLRSGRKCNFDKCKGTGVYNCGESCSCEGLHSCRCTYNIGSMKSGCACICTYY
Physicochemical Analysis
C440H709N129O131S15
W
C
10383.16
8.63
15
6
31
+7
12.53
-0.192
59.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6585
63.42
35
Residue Composition
number
4
A
6
R
3
N
2
D
10
C
4
E
4
Q
9
G
2
H
3
I
8
L
7
K
5
M
4
F
1
P
9
S
5
T
0
W
4
Y
3
V
Amino Acid Distribution
A: 4 R: 6 N: 3 D: 2 C: 10 E: 4 Q: 4 G: 9 H: 2 I: 3 L: 8 K: 7 M: 5 F: 4 P: 1 S: 9 T: 5 W: 0 Y: 4 V: 3
Chemical Descriptors
93
C440H709N129O131S15
10383.16
8.63
+7
12.53
-0.192
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin provokes a nearly complete and slowly reversible inhibition of both the human adult (alpha-1-beta-1-epsilon-delta (CHRNA1-CHRNB1-CHRND-CHRNE)) and human fetal (alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND)) neuromuscular nAChRs (PubMed:15910004, PubMed:26074268). It also reversibly blocks the neuromuscular alpha-7/CHRNA7 nAChR, the alpha-3-beta-2 (CHRNA3-CHRNB2) nAChR, the chimeric alpha-6 or -3/beta-3 or -2 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) nAChR and with a low potency the alpha-4-beta-2 (CHRNA4-CHRNB2) nAChR (PubMed:15910004). In addition, the toxin also inhibits the alpha-9-alpha-10 (CHRNA9-CHRNA10) nAChR with a high potency (IC(50)=187 nM) (PubMed:26074268). {ECO:0000269|PubMed:15910004, ECO:0000269|PubMed:26074268}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin provokes a nearly complete and slowly reversible inhibition of both the human adult (alpha-1-beta-1-epsilon-delta (CHRNA1-CHRNB1-CHRND-CHRNE)) and human fetal (alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND)) neuromuscular nAChRs (PubMed:15910004, PubMed:26074268).
Alpha-conotoxin RVIIIA (AlphaS-conotoxin RVIIIA)
cone snail
Conotoxin S superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:15910004}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin S superfamily
Alpha-conotoxin RVIIIA (AlphaS-conotoxin RVIIIA)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:15910004}.
cone snail