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Peptide record

TPDB72473

Neurotoxin standard
71 amino acids
Basic Information
3D PDB MODEL
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TPDB72473
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 71-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSALKFVLICGLVLLLIETIPGVSLNLMRATNRHQCDTNDDCEEDECCVLVGGNVNNPGVQTRICLACSRK
Physicochemical Analysis
C325H547N95O103S9
WY
L
7722.03
4.90
7
8
27
-2
14.63
0.275
109.72
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
4.86
22
Residue Composition
number
3
A
4
R
6
N
4
D
7
C
4
E
2
Q
5
G
1
H
4
I
10
L
2
K
2
M
1
F
2
P
3
S
4
T
0
W
0
Y
7
V
Amino Acid Distribution
A: 3 R: 4 N: 6 D: 4 C: 7 E: 4 Q: 2 G: 5 H: 1 I: 4 L: 10 K: 2 M: 2 F: 1 P: 2 S: 3 T: 4 W: 0 Y: 0 V: 7
Chemical Descriptors
71
C325H547N95O103S9
7722.03
4.90
-2
14.63
0.275
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Elicits an uncoordinated twisting syndrome when injected into C.elegans, but has no effect on mice.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Terebra subulata (Chocolate spotted auger) (Buccinum subulatum)
Neurotoxin
Elicits an uncoordinated twisting syndrome when injected into C.elegans, but has no effect on mice.
Augerpeptide-s7a (Agx-s7a)
other
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at protein level
Augerpeptide-s7a (Agx-s7a)
TISSUE SPECIFICITY: Expressed by the venom duct.
other