TPDB

3D PDB MODEL

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TPDB ID TPDB72472

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 242-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MIILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIKNLSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERVILGTAALNNRGLVEEAVKKYDEKIAIGIDAKNEKVAINGWLNVSSINYIDFAKEMEKIGVRNIIFTDISKDGTLKGPNLKQLEKLNESINCNVIASGGIKDIEDLKGIKEMDVYGAIVGKAIYSGNINLNEAIKIINKGSSK

FASTA

>TPDB72472|Neurotoxin|length=242
MIILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIKNLSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERVILGTAALNNRGLVEEAVKKYDEKIAIGIDAKNEKVAINGWLNVSSINYIDFAKEMEKIGVRNIIFTDISKDGTLKGPNLKQLEKLNESINCNVIASGGIKDIEDLKGIKEMDVYGAIVGKAIYSGNINLNEAIKIINKGSSK

Formula C1172H1944N308O355S6

Absent Amino Acids

Common Amino Acids I

Mass 26222.54

PI 5.53

Basic Residues 32

Acidic Residues 33

Hydrophobic Residues 107

Net Charge -2

Boman Index 61.26

Hydrophobicity 0.053

Aliphatic Index 120.91

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 14565

Absorbance 280nm 55.54

Polar Residues 48

number

18

A

5

R

20

N

14

D

2

C

19

E

2

Q

24

G

1

H

40

I

20

L

26

K

4

M

4

F

4

P

12

S

6

T

1

W

6

Y

14

V

Amino Acid Distribution

A: 18 R: 5 N: 20 D: 14 C: 2 E: 19 Q: 2 G: 24 H: 1 I: 40 L: 20 K: 26 M: 4 F: 4 P: 4 S: 12 T: 6 W: 1 Y: 6 V: 14

Length

242

Formula

C1172H1944N308O355S6

Mass

26222.54

PI

5.53

Net Charge

-2

Boman Index

61.26

Hydrophobicity

0.053

Evidence 1 Activity

Source & Reference

Database Source NA