TPDB

3D PDB MODEL

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TPDB ID TPDB72470

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 98-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MSTLGILLPIALLLPLANPAENGDGQAMPRTRNLRSLSFGRTLRRLEKRGCDPTDGCQTTVCETDTGPCCCKPNFTCQISNSGTKSCSCSGQPSDCPV

FASTA

>TPDB72470|Neurotoxin|length=98
MSTLGILLPIALLLPLANPAENGDGQAMPRTRNLRSLSFGRTLRRLEKRGCDPTDGCQTTVCETDTGPCCCKPNFTCQISNSGTKSCSCSGQPSDCPV

Formula C429H713N131O143S12

Absent Amino Acids HWY

Common Amino Acids L

Mass 10378.89

PI 7.72

Basic Residues 10

Acidic Residues 8

Hydrophobic Residues 24

Net Charge +2

Boman Index 19.23

Hydrophobicity -0.302

Aliphatic Index 65.71

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 625

Absorbance 280nm 6.02

Polar Residues 38

number

4

A

7

R

5

N

5

D

10

C

3

E

4

Q

9

G

0

H

3

I

11

L

3

K

2

M

2

F

9

P

9

S

10

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 4 R: 7 N: 5 D: 5 C: 10 E: 3 Q: 4 G: 9 H: 0 I: 3 L: 11 K: 3 M: 2 F: 2 P: 9 S: 9 T: 10 W: 0 Y: 0 V: 2

Length

98

Formula

C429H713N131O143S12

Mass

10378.89

PI

7.72

Net Charge

+2

Boman Index

19.23

Hydrophobicity

-0.302

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Injection of the synthetic peptide causes a hyperexcitable phenotype in mice greater than three weeks of age at lower doses, and lethargy at higher doses. {ECO:0000269|PubMed:18586046}.

Target

Target or Channel proton-gated sodium channel / ASIC

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Conus distans (Distant cone)

Neurotoxin Type Neurotoxin

Mechanism

Injection of the synthetic peptide causes a hyperexcitable phenotype in mice greater than three weeks of age at lower doses, and lethargy at higher doses..

Protein Name Conotoxin Di19A (Conotoxin di16a)

Venom Taxon Group cone snail

Protein Existence Evidence at protein level

Keywords Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Neurotoxin Secreted Signal Toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed by the venom duct.

Keywords

Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Neurotoxin Secreted Signal Toxin

Neurotoxin_Type

Neurotoxin

Protein_Existence

Evidence at protein level

Protein_Name

Conotoxin Di19A (Conotoxin di16a)

Tissue_Specificity

TISSUE SPECIFICITY: Expressed by the venom duct.

Venom_Taxon_Group

cone snail