TPDB

3D PDB MODEL

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TPDB ID TPDB72463

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 80-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MKNNYISTCIVYLMAALLLISVISIKECTADISDYGDPCSDDLKDYCIHGDCFFLKELNQPACRCYTGYYGSRCEHIDHN

FASTA

>TPDB72463|Neurotoxin|length=80
MKNNYISTCIVYLMAALLLISVISIKECTADISDYGDPCSDDLKDYCIHGDCFFLKELNQPACRCYTGYYGSRCEHIDHN

Formula C397H607N101O124S10

Absent Amino Acids W

Common Amino Acids DCI

Mass 9099.39

PI 4.61

Basic Residues 9

Acidic Residues 11

Hydrophobic Residues 32

Net Charge -5

Boman Index 10.60

Hydrophobicity -0.042

Aliphatic Index 85.38

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 10930

Absorbance 280nm 120.12

Polar Residues 29

number

4

A

2

R

4

N

8

D

8

C

3

E

1

Q

4

G

3

H

8

I

7

L

4

K

2

M

2

F

2

P

6

S

3

T

0

W

7

Y

2

V

Amino Acid Distribution

A: 4 R: 2 N: 4 D: 8 C: 8 E: 3 Q: 1 G: 4 H: 3 I: 8 L: 7 K: 4 M: 2 F: 2 P: 2 S: 6 T: 3 W: 0 Y: 7 V: 2

Length

80

Formula

C397H607N101O124S10

Mass

9099.39

PI

4.61

Net Charge

-5

Boman Index

10.60

Hydrophobicity

-0.042

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Ant peptide with probable defensive activity which acts as a potent agonist of the mammalian epidermal growth factor receptor (EGFR) (EC(50)=6.3 nM). Mimics, both structurally and functionally, vertebrate epidermal growth factor (EGF) peptide hormones. In vivo, intraplantar injection in mice causes long-lasting (several days) hypersensitivity of the injected paw to both mechanical and thermal stimuli. Its long-lasting effect is unusual for venom toxins whose effects are usually immediate. One possible explanation is that it would reduce the duration of a nest attack, discourage future attacks, or enhance the actions of subsequent exposure to other pain-inducing venom peptides. {ECO:0000269|PubMed:35131940}.

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Myrmecia gulosa (Red bulldog ant)

Neurotoxin Type Neurotoxin

Mechanism

Ant peptide with probable defensive activity which acts as a potent agonist of the mammalian epidermal growth factor receptor (EGFR) (EC(50)=6.3 nM). Mimics, both structurally and functionally, vertebrate epidermal growth factor (EGF) peptide hormones.

Protein Name OMEGA-myrmeciitoxin(02)-Mg1a (MIITX2-Mg1a) (OMEGA-MIITX(02)-Mg1a)

Venom Taxon Group insect

Protein Family EGF domain peptide family

Protein Existence Evidence at protein level

Keywords 3D-structure Disulfide bond EGF-like domain Neurotoxin Secreted Signal Toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30214940, ECO:0000305|PubMed:35131940}.

Keywords

3D-structure Disulfide bond EGF-like domain Neurotoxin Secreted Signal Toxin

Neurotoxin_Type

Neurotoxin

Protein_Existence

Evidence at protein level

Protein_Family

EGF domain peptide family

Protein_Name

OMEGA-myrmeciitoxin(02)-Mg1a (MIITX2-Mg1a) (OMEGA-MIITX(02)-Mg1a)

Tissue_Specificity

TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30214940, ECO:0000305|PubMed:35131940}.

Venom_Taxon_Group

insect