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Peptide record

TPDB72458

Neurotoxin standard
66 amino acids
Basic Information
3D PDB MODEL
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TPDB72458
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 66-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNTGFFFFVIMATGLVLTFDTIHAEDKLKCTKTDDCAKYCSQFTDVHPACLGGYCECLRWEGGISS
Physicochemical Analysis
C326H490N80O97S8
T
7338.43
4.82
7
8
26
-3
5.17
0.176
66.52
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
120.67
20
Residue Composition
number
4
A
1
R
1
N
5
D
6
C
3
E
1
Q
6
G
2
H
3
I
5
L
4
K
2
M
6
F
1
P
3
S
7
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 5 C: 6 E: 3 Q: 1 G: 6 H: 2 I: 3 L: 5 K: 4 M: 2 F: 6 P: 1 S: 3 T: 7 W: 1 Y: 2 V: 3
Chemical Descriptors
66
C326H490N80O97S8
7338.43
4.82
-3
5.17
0.176
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: inhibits Kv1.3/KCNA3 channel (1 uM of the toxin inhibits currents by 64.1%). {ECO:0000269|PubMed:22511981}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scorpiops margerisonae (Scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
inhibits Kv1.3/KCNA3 channel (1 uM of the toxin inhibits currents by 64.1%)..
Potassium channel toxin alpha-KTx 30.1 (Toxin SjKTx23) (Toxin StKTx23)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 30 subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at transcript level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 30 subfamily
Potassium channel toxin alpha-KTx 30.1 (Toxin SjKTx23) (Toxin StKTx23)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion