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Peptide record

TPDB72453

Neurotoxin standard
54 amino acids
Basic Information
3D PDB MODEL
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TPDB72453
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 54-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MDFLRILLFVLACIMALFTSAIAGGCIQRYGKCSTENSNCCAPSECYFSFNQCF
Physicochemical Analysis
C265H404N66O75S9
HW
C
6003.06
6.05
3
3
25
-0
-3.91
0.678
79.63
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
55.89
21
Residue Composition
number
5
A
2
R
3
N
1
D
7
C
2
E
2
Q
3
G
0
H
4
I
5
L
1
K
2
M
6
F
1
P
5
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 5 R: 2 N: 3 D: 1 C: 7 E: 2 Q: 2 G: 3 H: 0 I: 4 L: 5 K: 1 M: 2 F: 6 P: 1 S: 5 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
54
C265H404N66O75S9
6003.06
6.05
-0
-3.91
0.678
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P58608}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Platymeris rhadamanthus (Red spot assassin bug)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Binds reversibly and blocks P/Q-type voltage-gated calcium channels (Cav)..
U-reduvitoxin-Pr7a (U-RDTX-Pr7a)
insect
Venom Ptu1-like knottin family
Evidence at protein level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:31752210}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Venom Ptu1-like knottin family
U-reduvitoxin-Pr7a (U-RDTX-Pr7a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:31752210}.
insect