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Peptide record

TPDB72452

Neurotoxin standard
127 amino acids
Basic Information
3D PDB MODEL
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TPDB72452
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 127-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MFSTLIFLTAVTLLMMPSQTVPAPLKDVNDIRVKGLLPLLRQRQLQIMPSQTIPALKDVNDIRVKGLLSLLRQRKQEIMPSQTIPALKDVNDIRVKGLLSLLRQRKQEECDDPDGLMCCTISEMPTC
Physicochemical Analysis
C628H1073N175O182S11
HWY
L
14340.15
9.13
17
13
51
+4
28.49
-0.012
113.54
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
250
1.74
32
Residue Composition
number
4
A
9
R
3
N
9
D
4
C
4
E
10
Q
4
G
0
H
9
I
21
L
8
K
7
M
2
F
10
P
7
S
8
T
0
W
0
Y
8
V
Amino Acid Distribution
A: 4 R: 9 N: 3 D: 9 C: 4 E: 4 Q: 10 G: 4 H: 0 I: 9 L: 21 K: 8 M: 7 F: 2 P: 10 S: 7 T: 8 W: 0 Y: 0 V: 8
Chemical Descriptors
127
C628H1073N175O182S11
14340.15
9.13
+4
28.49
-0.012
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as a neurotoxin by inhibiting an ion channel. {ECO:0000250}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Iotyrris olangoensis (Sea snail) (Lophiotoma olangoensis)
Neurotoxin Ion channel impairing toxin
Acts as a neurotoxin by inhibiting an ion channel..
Turripeptide OL172 [Cleaved into: Turripeptide OL172 1 Turripeptide OL172 2 Turripeptide OL172 3 Turripeptide OL172 conotoxin-like]
other
Evidence at protein level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Repeat Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Pyrrolidone carboxylic acid Repeat Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Turripeptide OL172 [Cleaved into: Turripeptide OL172 1 Turripeptide OL172 2 Turripeptide OL172 3 Turripeptide OL172 conotoxin-like]
TISSUE SPECIFICITY: Expressed by the venom duct.
other