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Peptide record

TPDB72441

Neurotoxin standard
101 amino acids
Basic Information
3D PDB MODEL
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TPDB72441
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 101-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MVKSEMKLVIFSLFLLLIGVESLKNGYPVIEGGGSPDYGESAECGSEDSNSADNFCNDICTNVGGKSGDCCLGSCFCFDLPDEQKTVEVMDRTKEYCEFVE
Physicochemical Analysis
C471H728N116O162S11
HW
EG
10960.30
3.84
7
19
34
-12
26.96
-0.104
71.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4970
45.35
30
Residue Composition
number
2
A
1
R
5
N
8
D
8
C
11
E
1
Q
11
G
0
H
4
I
8
L
6
K
3
M
6
F
3
P
10
S
3
T
0
W
3
Y
8
V
Amino Acid Distribution
A: 2 R: 1 N: 5 D: 8 C: 8 E: 11 Q: 1 G: 11 H: 0 I: 4 L: 8 K: 6 M: 3 F: 6 P: 3 S: 10 T: 3 W: 0 Y: 3 V: 8
Chemical Descriptors
101
C471H728N116O162S11
10960.30
3.84
-12
26.96
-0.104
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus pachyurus (Colombian scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity)..
Toxin Tpa8 (T NaTx9.1)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Toxin Tpa8 (T NaTx9.1)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion