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Peptide record

TPDB72440

Neurotoxin standard
60 amino acids
Basic Information
3D PDB MODEL
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TPDB72440
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 60-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNRLTTIILMLIVINVIMDDISESKVAAGIVCKVCKIICGMQGKKVNICKAPIKCKCKKG
Physicochemical Analysis
C284H509N77O75S10
HFWY
I
6523.24
9.79
11
3
27
+8
10.52
0.665
125.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
5.75
14
Residue Composition
number
3
A
1
R
3
N
2
D
6
C
1
E
1
Q
4
G
0
H
11
I
3
L
10
K
4
M
0
F
1
P
2
S
2
T
0
W
0
Y
6
V
Amino Acid Distribution
A: 3 R: 1 N: 3 D: 2 C: 6 E: 1 Q: 1 G: 4 H: 0 I: 11 L: 3 K: 10 M: 4 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 0 V: 6
Chemical Descriptors
60
C284H509N77O75S10
6523.24
9.79
+8
10.52
0.665
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits potassium channels..
Putative potassium channel blocker TXKS1 (BmTXKS1)
scorpion
Evidence at protein level
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 6 fields
Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Putative potassium channel blocker TXKS1 (BmTXKS1)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion