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Peptide record

TPDB72439

Neurotoxin standard
63 amino acids
Basic Information
3D PDB MODEL
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TPDB72439
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 63-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MQFSGVVLILISMTLVNFVFFETKVEAGKFGKCKPNICAKTCQTEKGKGMGYCNKTECVCSEW
Physicochemical Analysis
C311H493N77O88S9
RDH
K
7007.34
8.30
8
5
24
+3
8.94
0.160
67.94
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
105.10
20
Residue Composition
number
2
A
0
R
3
N
0
D
6
C
5
E
2
Q
6
G
0
H
3
I
3
L
8
K
3
M
5
F
1
P
3
S
5
T
1
W
1
Y
6
V
Amino Acid Distribution
A: 2 R: 0 N: 3 D: 0 C: 6 E: 5 Q: 2 G: 6 H: 0 I: 3 L: 3 K: 8 M: 3 F: 5 P: 1 S: 3 T: 5 W: 1 Y: 1 V: 6
Chemical Descriptors
63
C311H493N77O88S9
7007.34
8.30
+3
8.94
0.160
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly and voltage-independently blocks voltage-gated potassium channels rKv1.2/KCNA2 (73%) (IC(50)=196 nM), hKv1.3/KCNA3 (50%) (IC(50)=508 nM), Shaker IR (30%), rKv1.6/KCNA6 (22%) (at 0.5 uM). Interaction of Ts15 with Kv1.3/KCNA3 is stronger than its interaction with Kv1.2/KCNA2. {ECO:0000269|PubMed:21600910}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus serrulatus (Brazilian yellow scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Reversibly and voltage-independently blocks voltage-gated potassium channels rKv1.2/KCNA2 (73%) (IC(50)=196 nM), hKv1.3/KCNA3 (50%) (IC(50)=508 nM), Shaker IR (30%), rKv1.6/KCNA6 (22%) (at 0.5 uM). Interaction of Ts15 with Kv1.3/KCNA3 is stronger than its interaction with Kv1.2/KCNA2..
Potassium channel toxin alpha-KTx 21.1 (Tityustoxin-15) (Ts15)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 21 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25199494}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 21 subfamily
Potassium channel toxin alpha-KTx 21.1 (Tityustoxin-15) (Ts15)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25199494}.
scorpion