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Peptide record

TPDB72433

Neurotoxin standard
78 amino acids
Basic Information
3D PDB MODEL
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TPDB72433
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 78-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
AELKSCFPVGHECDDDASNCNCCGDDVYCACGWGRWNCKCKVADQSYAYGICKDKVNCPNRHLWPAKECKMPCRRNCG
Physicochemical Analysis
C363H553N111O112S15
T
C
8744.96
7.26
13
10
21
+1
16.85
-0.636
37.56
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
21845
249.80
27
Residue Composition
number
6
A
4
R
6
N
7
D
14
C
3
E
1
Q
6
G
2
H
1
I
2
L
7
K
1
M
1
F
4
P
3
S
0
T
3
W
3
Y
4
V
Amino Acid Distribution
A: 6 R: 4 N: 6 D: 7 C: 14 E: 3 Q: 1 G: 6 H: 2 I: 1 L: 2 K: 7 M: 1 F: 1 P: 4 S: 3 T: 0 W: 3 Y: 3 V: 4
Chemical Descriptors
78
C363H553N111O112S15
8744.96
7.26
+1
16.85
-0.636
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Lethal neurotoxin. Causes spastic paralysis and death in mice in 4-6 minutes after intracerebroventricular injection at dose levels of 1.5 ug per mouse. {ECO:0000269|Ref.2}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Neurotoxin
Lethal neurotoxin. Causes spastic paralysis and death in mice in 4-6 minutes after intracerebroventricular injection at dose levels of 1.5 ug per mouse..
U5-ctenitoxin-Pk1a (U5-CNTX-Pk1a) (Neurotoxin PKTx15C1) (Neurotoxin PKTx1A)
spider
Neurotoxin 04 (omega-agtx) family, 02 (Tx1) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 02 (Tx1) subfamily
U5-ctenitoxin-Pk1a (U5-CNTX-Pk1a) (Neurotoxin PKTx15C1) (Neurotoxin PKTx1A)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100}.
spider