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Peptide record

TPDB72430

Neurotoxin standard
69 amino acids
Basic Information
3D PDB MODEL
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TPDB72430
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 69-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSKLGVVLFVFLLLLPLAAPQPVGDQPADQPADRNAEARARFLHPFQYYTLYRYLTRFLHRYPIYYIRY
Physicochemical Analysis
C392H586N100O94S1
CW
L
8235.64
9.89
10
4
38
+4
-0.48
-0.026
100.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11920
144.74
16
Residue Composition
number
7
A
7
R
1
N
3
D
0
C
1
E
4
Q
2
G
2
H
2
I
11
L
1
K
1
M
5
F
7
P
1
S
2
T
0
W
8
Y
4
V
Amino Acid Distribution
A: 7 R: 7 N: 1 D: 3 C: 0 E: 1 Q: 4 G: 2 H: 2 I: 2 L: 11 K: 1 M: 1 F: 5 P: 7 S: 1 T: 2 W: 0 Y: 8 V: 4
Chemical Descriptors
69
C392H586N100O94S1
8235.64
9.89
+4
-0.48
-0.026
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Tyrosine-rich conopeptide that targets several channels/receptors that are expressed in Xenopus oocytes. These targets are the voltage-gated potassium channels Kv1.6/KCNA6 (IC(50) is 170 nM) and Kv1.2/KCNA2 (IC(50) is 2.0 uM), Nav1.2/SCN2A (30% of inhibition), and N-methyl-D-aspartate (NMDA) receptor (GRIN1/GRIN2A/GRIN3B and GRIN1/GRIN2B/GRIN3B) (15% of inhibition). In vivo, causes the marine worm N.virens to move very slowly in contrast to control worms, and causes seizures (at 5 nmol) and death (20 nmol) to mice when intracranially injected. {ECO:0000269|PubMed:18505731}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv) glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus planorbis (Planorbis cone)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Tyrosine-rich conopeptide that targets several channels/receptors that are expressed in Xenopus oocytes. These targets are the voltage-gated potassium channels Kv1.6/KCNA6 (IC(50) is 170 nM) and Kv1.2/KCNA2 (IC(50) is 2.0 uM), Nav1.2/SCN2A (30% of inhibition), and N-methyl-D-aspartate (NMDA) receptor (GRIN1/GRIN2A/GRIN3B and GRIN1/GRIN2B/GRIN3B) (15% of inhibition).
Conopeptide Y-Pl1 (CPY-Pl1)
cone snail
Conotoxin M superfamily, Conopeptide Y family
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Neurotoxin Postsynaptic neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Neurotoxin Postsynaptic neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily, Conopeptide Y family
Conopeptide Y-Pl1 (CPY-Pl1)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail