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Peptide record

TPDB72421

Neurotoxin standard
1418 amino acids
Basic Information
3D PDB MODEL
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TPDB72421
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 1418-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MIFVGETMERANHSLVRLRREGEELTLDEKAEICSELELQQKYVDIASNIIGDLSSLPMVGKIVGTIAAAAMTVTHVASGRLDIEQTLLGCSDLPFDQIKEVLEKRFNEVDRKLESHSAALEEITKLVEKSISAVEKTRKQMNKRFDEVMKSIQDAKVSPIVSKINNFARYFDTEKERIRGLKLNDYILKLEEPNGILLHFKESRTPKDDSLQAPLFSIIQEGYAVPKSIDDESAFKVLYALLYGTQTYISVMFFLLEQYSFLANHYYEKGDLEKYDEYFNSLNNVFLDFKSSLVGTGTSNNEGLIDKVLQVLMTFKNSEFLGLGKNGVDEMLNEKINLFNKIKEEIESKQRMTMSETPENFAQISFDKDITTPIGDWRDGREVRYAVQYASETLFSKIGHWSDPVSVREKACPTLRMPVDQTRRNVLVFRKFDNSKPQLVGEITPYLSNFIDIDRDLYNAASNPDSAVGFKEFTKLNYDGANIRATFDQGRTIFHAVAKSGNDKILFGLTFLVKSTELNQPDKKGYTPIHVAADSGNAGIVNLLIQRGVSINSKTYHFLQTPLHLAAQRGFVNTFQRLMESSEININERDKDGFTPLHYAVRGGERILEAFMNQIGIDVNAKSNKGLTPFHLAIIKNDWQVASTLLRNKKVDINAVDENNMTALHYAAILGYLETTKQLINLKEINANVVSSPGLLSALHYAILYKHDDVASFLLRSSNVNVNLKALGGITPLHLAVMQGRKQVLSLMFNIGVNIEQQTDEKYTPLHLAAMSKYPELIQILLDQDSNFEAKTNSGATPLHLATFKGKSQAALILLNNEVNWRDTDENGQMPIHGAATTGLLDVAQAIISIDATVLDIEDKNSDTPLNLAAQNSHIDAVKYFIDQGADINTRNKNGHAPLLAFSKKGNLDMVKYLFDKNANVYIADNNGMNFFYYAVRNGHLNIIKYAMSEKDKFEWSNIDNNRRDECPKEECAISHFAVCDAVQFDKIEIVKFFIGTLGNFNICGPLHQAARYGHLHIVKYLVEEEVLSVDGSKTDTPLCYASENGHLAVVQYLVSNGAKVNHDCANGMTAIDKAITKNHLQVVQFLAANGVDFRRKNSRGATPFLTAVAENAFDIAEYLIREKRQDININEQNVDKETALHLAVYYKNLQMIKLLVKYGIDVTIRNAYDKTVLDIATDAKFSNIVKYLKKNSGKFRREYKSSYGEHSFLQTNEISRFIDGKSIEHDHPQFINADNESSQLFSGTASKIDVIGTLLLIDVLIRYFSKQGYISKESDSASDGITQAAALSITEKFEDVLNSLPNKSAKEQVDLADVHGKVYAALKSGRNSQIHQILCSSLKSISTLKPEDMEKLVSVIMNSHSSLSMPEATDSANEAYGETLHLFGESCRHSEDYISQKFSTNPFSFESEKKIQKISI
Physicochemical Analysis
C7089H11192N1916O2165S38
L
159120.66
5.90
197
183
584
-21
335.65
-0.301
91.97
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
101135
63.56
391
Residue Composition
number
107
A
52
R
100
N
90
D
11
C
93
E
54
Q
75
G
38
H
105
I
138
L
107
K
27
M
67
F
37
P
107
S
70
T
5
W
49
Y
86
V
Amino Acid Distribution
A: 107 R: 52 N: 100 D: 90 C: 11 E: 93 Q: 54 G: 75 H: 38 I: 105 L: 138 K: 107 M: 27 F: 67 P: 37 S: 107 T: 70 W: 5 Y: 49 V: 86
Chemical Descriptors
1418
C7089H11192N1916O2165S38
159120.66
5.90
-21
335.65
-0.301
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Presynaptic neurotoxin that causes massive release of neurotransmitters from vertebrate (but not invertebrate) nerve terminals and endocrine cells via a complex mechanism involving activation of receptor(s) and toxin insertion into the plasma membrane with subsequent pore formation. Binds to neurexin-1-alpha (NRXN1) in a calcium dependent manner, adhesion G protein-coupled receptor L1 (ADGRL1, also termed latrophilin-1 and calcium-independent receptor of latrotoxin (CIRL)), and receptor-type tyrosine-protein phosphatase S (PTPRS), also termed PTP sigma. NRXN1 and PTPRS are suggested to provide a platform for binding and subsequent pore formation events. In contrast, binding to ADGRL1 does not involve oligomerization and channel formation, but direct downstream stimulation of the synaptic fusion machinery. {ECO:0000250|UniProtKB:P23631}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Latrodectus hesperus (Western black widow spider)
Neurotoxin Presynaptic neurotoxin
Presynaptic neurotoxin that causes massive release of neurotransmitters from vertebrate (but not invertebrate) nerve terminals and endocrine cells via a complex mechanism involving activation of receptor(s) and toxin insertion into the plasma membrane with subsequent pore formation. Binds to neurexin-1-alpha (NRXN1) in a calcium dependent manner, adhesion G protein-coupled receptor L1 (ADGRL1, also termed latrophilin-1 and calcium-independent receptor of latrotoxin (CIRL)), and receptor-type tyrosine-protein phosphatase S (PTPRS), also termed PTP sigma.
Alpha-latrotoxin-Lhe1a (Alpha-LTX-Lhe1a) (Alpha-latrotoxin) (Alpha-LTX)
spider
Cationic peptide 01 (latrotoxin) family, 03 (alpha-latrotoxin) subfamily
Evidence at protein level
ANK repeat Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Exocytosis Membrane Neurotoxin Presynaptic neurotoxin Repeat Secreted Signal Target cell membrane Target membrane Toxin Transmembrane
TISSUE SPECIFICITY: Expressed in venom gland, cephalothorax, and abdomen tissues from both males and females. {ECO:0000250|UniProtKB:P0DJE4}.
Additional Detail Fields 7 fields
ANK repeat Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Exocytosis Membrane Neurotoxin Presynaptic neurotoxin Repeat Secreted Signal Target cell membrane Target membrane Toxin Transmembrane
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Cationic peptide 01 (latrotoxin) family, 03 (alpha-latrotoxin) subfamily
Alpha-latrotoxin-Lhe1a (Alpha-LTX-Lhe1a) (Alpha-latrotoxin) (Alpha-LTX)
TISSUE SPECIFICITY: Expressed in venom gland, cephalothorax, and abdomen tissues from both males and females. {ECO:0000250|UniProtKB:P0DJE4}.
spider