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Peptide record

TPDB72416

Neurotoxin standard
61 amino acids
Basic Information
3D PDB MODEL
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TPDB72416
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 61-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNAKFILLLLVVTTTTLLPDAKGAEIIRCSGTRECYAPCQKLTGCLNAKCMNKACKCYGCV
Physicochemical Analysis
C284H479N77O81S10
HW
CL
6588.99
8.51
8
3
25
+5
4.97
0.403
94.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3480
52.82
21
Residue Composition
number
6
A
2
R
3
N
1
D
8
C
2
E
1
Q
4
G
0
H
3
I
8
L
6
K
2
M
1
F
2
P
1
S
6
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 6 R: 2 N: 3 D: 1 C: 8 E: 2 Q: 1 G: 4 H: 0 I: 3 L: 8 K: 6 M: 2 F: 1 P: 2 S: 1 T: 6 W: 0 Y: 2 V: 3
Chemical Descriptors
61
C284H479N77O81S10
6588.99
8.51
+5
4.97
0.403
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels (PubMed:29483648). {ECO:0000269|PubMed:29483648}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Opistophthalmus carinatus (African yellow leg scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels (PubMed:29483648)..
Potassium channel toxin alpha-KTx 6.9 (OcKTx4)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Evidence at protein level
3D-structure Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:14696198}.
Additional Detail Fields 7 fields
3D-structure Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 06 subfamily
Potassium channel toxin alpha-KTx 6.9 (OcKTx4)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:14696198}.
scorpion