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Peptide record

TPDB72408

Neurotoxin standard
72 amino acids
Basic Information
3D PDB MODEL
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TPDB72408
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 72-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MRVSYLSLTLTIVVVIAIIYAPETEAKAWADADAEAGLGFLAKIMGKVGMRMIKKLVPEAAKVAVDQLSQQQ
Physicochemical Analysis
C351H583N89O99S4
NCH
A
7762.27
9.33
8
7
41
+1
10.36
0.493
119.31
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8480
109.25
12
Residue Composition
number
12
A
2
R
0
N
3
D
0
C
4
E
4
Q
4
G
0
H
6
I
7
L
6
K
4
M
1
F
2
P
3
S
3
T
1
W
2
Y
8
V
Amino Acid Distribution
A: 12 R: 2 N: 0 D: 3 C: 0 E: 4 Q: 4 G: 4 H: 0 I: 6 L: 7 K: 6 M: 4 F: 1 P: 2 S: 3 T: 3 W: 1 Y: 2 V: 8
Chemical Descriptors
72
C351H583N89O99S4
7762.27
9.33
+1
10.36
0.493
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: [U10-myrmicitoxin-Tb1a]: In vivo, this neurotoxin paralyzes about 40% of blowflies (L.caesar) one hour after intrathoracic injection, when tested at high doses (28 nmol/g). {ECO:0000269|PubMed:37888631}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tetramorium bicarinatum (Tramp ant)
Neurotoxin
[U10-myrmicitoxin-Tb1a]: In vivo, this neurotoxin paralyzes about 40% of blowflies (L.caesar) one hour after intrathoracic injection, when tested at high doses (28 nmol/g)..
U10-myrmicitoxin-Tb1a (U10-MYRTX-Tb1a) [Cleaved into: U10-myrmicitoxin-Tb1a (cleaved) (Cleaved U10-MYRTX-Tb1a (cleaved))]
insect
Formicidae venom precursor-01 superfamily
Evidence at protein level
Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30149710}.
Additional Detail Fields 7 fields
Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at protein level
Formicidae venom precursor-01 superfamily
U10-myrmicitoxin-Tb1a (U10-MYRTX-Tb1a) [Cleaved into: U10-myrmicitoxin-Tb1a (cleaved) (Cleaved U10-MYRTX-Tb1a (cleaved))]
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:30149710}.
insect