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Peptide record

TPDB72399

Neurotoxin standard
79 amino acids
Basic Information
3D PDB MODEL
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TPDB72399
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 79-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKVLVAVLVFALLMCMFVDIAESRRRDNPEYPSGLRYDEEMGVFKRCAQTGGTCSKSKDCCIVTAICSTATSPKTCFYG
Physicochemical Analysis
C377H607N101O113S11
HW
CV
8715.24
7.92
10
8
32
+2
11.82
0.156
72.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
55.59
24
Residue Composition
number
6
A
5
R
1
N
4
D
7
C
4
E
1
Q
5
G
0
H
3
I
5
L
5
K
4
M
4
F
3
P
6
S
6
T
0
W
3
Y
7
V
Amino Acid Distribution
A: 6 R: 5 N: 1 D: 4 C: 7 E: 4 Q: 1 G: 5 H: 0 I: 3 L: 5 K: 5 M: 4 F: 4 P: 3 S: 6 T: 6 W: 0 Y: 3 V: 7
Chemical Descriptors
79
C377H607N101O113S11
8715.24
7.92
+2
11.82
0.156
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-toxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin very weakly competes with alpha-bungarotoxin for binding to orthosteric sites on muscle-type T.carlifornicus (IC(50)=14.95 uM) and human alpha-7/CHRNA7 nAChRs (IC(50)>45 uM). {ECO:0000269|PubMed:36668848}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Metridium senile (Brown sea anemone) (Frilled sea anemone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Alpha-toxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin very weakly competes with alpha-bungarotoxin for binding to orthosteric sites on muscle-type T.carlifornicus (IC(50)=14.95 uM) and human alpha-7/CHRNA7 nAChRs (IC(50)>45 uM)..
Alpha-actitoxin-Ms11a-4 (Alpha-AITX-Ms11a-4) (Alpha-anmTX-Ms11a-4)
sea anemone
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Knottin Nematocyst Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
Additional Detail Fields 5 fields
Acetylcholine receptor inhibiting toxin Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Knottin Nematocyst Neurotoxin Postsynaptic neurotoxin Secreted Signal Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Alpha-actitoxin-Ms11a-4 (Alpha-AITX-Ms11a-4) (Alpha-anmTX-Ms11a-4)
sea anemone