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Peptide record

TPDB72395

Neurotoxin standard
70 amino acids
Basic Information
3D PDB MODEL
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TPDB72395
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 70-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MESSRKSYVLMLFLAFVIMNVCSVSGEPKDGEIAGFEMEEARYDACVNACLEHHPNVRECEEACKNPVPP
Physicochemical Analysis
C337H526N90O106S9
QTW
E
7822.96
4.49
8
12
28
-6
23.81
-0.150
71.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3230
41.29
16
Residue Composition
number
6
A
3
R
4
N
2
D
5
C
10
E
0
Q
3
G
2
H
2
I
4
L
3
K
4
M
3
F
5
P
5
S
0
T
0
W
2
Y
7
V
Amino Acid Distribution
A: 6 R: 3 N: 4 D: 2 C: 5 E: 10 Q: 0 G: 3 H: 2 I: 2 L: 4 K: 3 M: 4 F: 3 P: 5 S: 5 T: 0 W: 0 Y: 2 V: 7
Chemical Descriptors
70
C337H526N90O106S9
7822.96
4.49
-6
23.81
-0.150
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-independently blocks potassium currents on hKv1.1/KCNA1 (IC(50)=217 uM), and hKv1.4/KCNA4 (IC(50)=71 uM) (expressed in CHO cells). {ECO:0000269|PubMed:21624408}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Opisthacanthus cayaporum (South American scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Voltage-independently blocks potassium currents on hKv1.1/KCNA1 (IC(50)=217 uM), and hKv1.4/KCNA4 (IC(50)=71 uM) (expressed in CHO cells)..
Potassium channel toxin kappa-KTx 2.5 (OcyC8) (OcyKTx6)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18502464, ECO:0000305|PubMed:21624408}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily
Potassium channel toxin kappa-KTx 2.5 (OcyC8) (OcyKTx6)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18502464, ECO:0000305|PubMed:21624408}.
scorpion