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Peptide record

TPDB72390

Neurotoxin standard
82 amino acids
Basic Information
3D PDB MODEL
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TPDB72390
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 82-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
SKKEIPGGYPVNQFKCTYECAHADTDHIRCKNLCKKLGGSWGYCYWNTCYCEYLPDSVPQKNSIEVFSCGATIVGVPDTEQQ
Physicochemical Analysis
C405H608N106O125S8
M
C
9218.40
6.05
10
9
25
-1
15.75
-0.539
54.63
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
20440
221.73
32
Residue Composition
number
3
A
1
R
4
N
4
D
8
C
5
E
4
Q
7
G
2
H
4
I
3
L
7
K
0
M
2
F
5
P
5
S
5
T
2
W
6
Y
5
V
Amino Acid Distribution
A: 3 R: 1 N: 4 D: 4 C: 8 E: 5 Q: 4 G: 7 H: 2 I: 4 L: 3 K: 7 M: 0 F: 2 P: 5 S: 5 T: 5 W: 2 Y: 6 V: 5
Chemical Descriptors
82
C405H608N106O125S8
9218.40
6.05
-1
15.75
-0.539
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable sodium channel inhibitor. {ECO:0000305}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides sculpturatus (Arizona bark scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Probable sodium channel inhibitor..
Toxin NaTx-13
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:34357973}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Toxin NaTx-13
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:34357973}.
scorpion