TPDB

3D PDB MODEL

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TPDB ID TPDB72385

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 281-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MKNIGININTDKDISRNILDKIFQYIHEECSEAKIKVFYDSKGLDNEESRALDAVMVLGGDGTILGTARALAKYDVPIFGINRGHLGFLAEIELEDCKKAIKNLFKGQYKIEDRIMLKCDLKGIDKKDDFLALNDIVLTKGNLSRIVKYSIYVDDVWYTTFVADGVIVATPTGSTAYSLSAGGPIVYPDLDVLEIAPICPHSLGIRPILLNGNSKINIRVLKKYEDPVLTIDGQRYKKVTVNEVTISKSEYKCRLIKFKDKDYFKILRTKISYRSRECEGE

FASTA

>TPDB72385|Neurotoxin|length=281
MKNIGININTDKDISRNILDKIFQYIHEECSEAKIKVFYDSKGLDNEESRALDAVMVLGGDGTILGTARALAKYDVPIFGINRGHLGFLAEIELEDCKKAIKNLFKGQYKIEDRIMLKCDLKGIDKKDDFLALNDIVLTKGNLSRIVKYSIYVDDVWYTTFVADGVIVATPTGSTAYSLSAGGPIVYPDLDVLEIAPICPHSLGIRPILLNGNSKINIRVLKKYEDPVLTIDGQRYKKVTVNEVTISKSEYKCRLIKFKDKDYFKILRTKISYRSRECEGE

Formula C1427H2299N373O420S9

Absent Amino Acids

Common Amino Acids I

Mass 31689.74

PI 8.22

Basic Residues 46

Acidic Residues 40

Hydrophobic Residues 117

Net Charge +3

Boman Index 66.81

Hydrophobicity -0.187

Aliphatic Index 104.06

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 26735

Absorbance 280nm 84.36

Polar Residues 64

number

14

A

13

R

13

N

24

D

6

C

16

E

3

Q

20

G

3

H

32

I

26

L

30

K

3

M

9

F

8

P

15

S

13

T

1

W

14

Y

18

V

Amino Acid Distribution

A: 14 R: 13 N: 13 D: 24 C: 6 E: 16 Q: 3 G: 20 H: 3 I: 32 L: 26 K: 30 M: 3 F: 9 P: 8 S: 15 T: 13 W: 1 Y: 14 V: 18

Length

281

Formula

C1427H2299N373O420S9

Mass

31689.74

PI

8.22

Net Charge

+3

Boman Index

66.81

Hydrophobicity

-0.187

Evidence 1 Activity

Source & Reference

Database Source NA