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Peptide record

TPDB72382

Neurotoxin standard
58 amino acids
Basic Information
3D PDB MODEL
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TPDB72382
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 58-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
LKCYGIFRKIMTCPQGQNICEKFAYSPMHNGWMYSWGCTSNCHKGPLDKCCSTDLCNY
Physicochemical Analysis
C290H434N78O82S11
V
C
6677.77
8.09
8
3
18
+3
2.23
-0.397
42.07
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
17460
261.46
25
Residue Composition
number
1
A
1
R
4
N
2
D
8
C
1
E
2
Q
5
G
2
H
3
I
3
L
5
K
3
M
2
F
3
P
4
S
3
T
2
W
4
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 4 D: 2 C: 8 E: 1 Q: 2 G: 5 H: 2 I: 3 L: 3 K: 5 M: 3 F: 2 P: 3 S: 4 T: 3 W: 2 Y: 4 V: 0
Chemical Descriptors
58
C290H434N78O82S11
6677.77
8.09
+3
2.23
-0.397
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to and inhibits the endogenous nicotinic acetylcholine receptors (nAChR) in the human rhabdomyosarcoma TE 671 cell line with an IC(50) of 266 mM. Not toxic to mice by intraperitoneal injection or to zebrafish by injection at the back dorsolateral region. {ECO:0000269|PubMed:18384102}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Micrurus surinamensis (Surinam coral snake)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to and inhibits the endogenous nicotinic acetylcholine receptors (nAChR) in the human rhabdomyosarcoma TE 671 cell line with an IC(50) of 266 mM.
Short neurotoxin MS11 (Three-finger toxin) (3FTx)
snake
Three-finger toxin family, Short-chain subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Short-chain subfamily
Short neurotoxin MS11 (Three-finger toxin) (3FTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake