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Peptide record

TPDB72367

Neurotoxin standard
68 amino acids
Basic Information
3D PDB MODEL
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TPDB72367
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 68-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKLSCGFLLIFLVLSAMIATFSEVEATVKCGGCNRKCCPGGCRSGKCINGKCQCYGRSDLNEEFENYQ
Physicochemical Analysis
C316H506N88O96S11
HW
C
7426.69
7.78
8
6
23
+2
9.40
0.059
68.82
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3480
46.86
24
Residue Composition
number
3
A
3
R
4
N
1
D
9
C
5
E
2
Q
8
G
0
H
3
I
6
L
5
K
2
M
4
F
1
P
5
S
2
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 3 R: 3 N: 4 D: 1 C: 9 E: 5 Q: 2 G: 8 H: 0 I: 3 L: 6 K: 5 M: 2 F: 4 P: 1 S: 5 T: 2 W: 0 Y: 2 V: 3
Chemical Descriptors
68
C316H506N88O96S11
7426.69
7.78
+2
9.40
0.059
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable weak potassium channel blocker. {ECO:0000250|UniProtKB:P0C175}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus serrulatus (Brazilian yellow scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Probable weak potassium channel blocker..
Peptide TsPep3 (Tityustoxin-13) (Ts13)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Epsilon-KTx 01 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Epsilon-KTx 01 subfamily
Peptide TsPep3 (Tityustoxin-13) (Ts13)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion