TPDB

3D PDB MODEL

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TPDB ID TPDB72362

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 249-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MMAGRKGYQSVMDENCHDKTESAYTDDRSLNGSSGSSCLKNNVIAFFLGAAVVAATQYVSIDSSLTKAVEVTSFTTSDAPAIDIAINPTRPSLDARQDFKIEGWGNQTRNDGWPSFHFEVFHFCPHLINFMYENQVHPQSRVDPSNVIYDAQHPGALAEDGFAEVLQQTLPKFYDYPVGYRLNDRPAEISAYWTLHMRIARGSEDSQWHDFASSLPEGINRIYVKKPLQWNGDHVTLFSSQTGYNILVY

FASTA

>TPDB72362|Neurotoxin|length=249
MMAGRKGYQSVMDENCHDKTESAYTDDRSLNGSSGSSCLKNNVIAFFLGAAVVAATQYVSIDSSLTKAVEVTSFTTSDAPAIDIAINPTRPSLDARQDFKIEGWGNQTRNDGWPSFHFEVFHFCPHLINFMYENQVHPQSRVDPSNVIYDAQHPGALAEDGFAEVLQQTLPKFYDYPVGYRLNDRPAEISAYWTLHMRIARGSEDSQWHDFASSLPEGINRIYVKKPLQWNGDHVTLFSSQTGYNILVY

Formula C1249H1869N339O382S8

Absent Amino Acids

Common Amino Acids S

Mass 28002.10

PI 5.15

Basic Residues 28

Acidic Residues 29

Hydrophobic Residues 99

Net Charge -9

Boman Index 41.68

Hydrophobicity -0.419

Aliphatic Index 70.52

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 45505

Absorbance 280nm 162.51

Polar Residues 77

number

20

A

11

R

14

N

18

D

3

C

11

E

12

Q

15

G

9

H

13

I

15

L

8

K

5

M

13

F

13

P

23

S

13

T

5

W

12

Y

16

V

Amino Acid Distribution

A: 20 R: 11 N: 14 D: 18 C: 3 E: 11 Q: 12 G: 15 H: 9 I: 13 L: 15 K: 8 M: 5 F: 13 P: 13 S: 23 T: 13 W: 5 Y: 12 V: 16

Length

249

Formula

C1249H1869N339O382S8

Mass

28002.10

PI

5.15

Net Charge

-9

Boman Index

41.68

Hydrophobicity

-0.419

Evidence 1 Activity

Source & Reference

Database Source NA