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Peptide record

TPDB72351

Neurotoxin standard
75 amino acids
Basic Information
3D PDB MODEL
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TPDB72351
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 75-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MMLLVLSISAILQVSHSVSFCLLPIVPGPCTQYVIRYAFQPSISACRRFTFGGCEGNDNNFMTRRDCEHYCEELL
Physicochemical Analysis
C375H584N100O107S9
KW
L
8493.91
6.04
7
6
32
-1
5.89
0.313
90.93
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
57.04
25
Residue Composition
number
3
A
5
R
3
N
2
D
6
C
4
E
3
Q
4
G
2
H
5
I
8
L
0
K
3
M
5
F
4
P
7
S
3
T
0
W
3
Y
5
V
Amino Acid Distribution
A: 3 R: 5 N: 3 D: 2 C: 6 E: 4 Q: 3 G: 4 H: 2 I: 5 L: 8 K: 0 M: 3 F: 5 P: 4 S: 7 T: 3 W: 0 Y: 3 V: 5
Chemical Descriptors
75
C375H584N100O107S9
8493.91
6.04
-1
5.89
0.313
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: May exert inhibitory effects on serine proteases and on potassium and/or calcium channels and then participate in the long-term non-lethal paralysis on the prey. {ECO:0000305|PubMed:15823549}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anoplius samariensis (Solitary wasp)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
May exert inhibitory effects on serine proteases and on potassium and/or calcium channels and then participate in the long-term non-lethal paralysis on the prey..
Kunitz-type serine protease inhibitor As-fr-19 (Asfr19)
insect
Venom Kunitz-type family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Protease inhibitor Secreted Serine protease inhibitor Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15823549}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Protease inhibitor Secreted Serine protease inhibitor Signal Toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Venom Kunitz-type family
Kunitz-type serine protease inhibitor As-fr-19 (Asfr19)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15823549}.
insect