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Peptide record

TPDB72343

Neurotoxin standard
355 amino acids
Basic Information
3D PDB MODEL
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TPDB72343
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 355-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKLTYILLIAVVGVAIEAKSVKKSKAHHKKKRHETLADNYKLNRIKDSDCKDVADDCKAFGKLEKDDENSCFNNPDKARNECPVSCKLCVSKRSKKQSDYMGGYDLQPQQCSQQSCYETPQWSVQNCAVTCQLCQPGVSSGPVDQDVRCPFWGQYGYCSQQQQQQQTDGYISNNCPFSCNTYGSAQPAQQPYPYPIEALSPYQPNAMPTPPQGVTPAPLPPYFQQQGYGYPQQPQPTQPVQPGQTQAPTAAQSTPAPVQTTPASGKTTTEAAEETTTEAAAEGAETTAAPAATQAPAAAGQEGQQPAAGGQEPQEAQEQEGQQPGTEPAQSDKSNKKKHKKDKAQKKSKSHKKQH
Physicochemical Analysis
C1655H2585N477O550S18
Q
38541.68
7.54
43
35
95
+2
114.74
-1.039
41.63
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
34225
88.80
139
Residue Composition
number
38
A
5
R
12
N
16
D
15
C
19
E
49
Q
22
G
6
H
6
I
11
L
32
K
3
M
5
F
36
P
24
S
24
T
2
W
15
Y
15
V
Amino Acid Distribution
A: 38 R: 5 N: 12 D: 16 C: 15 E: 19 Q: 49 G: 22 H: 6 I: 6 L: 11 K: 32 M: 3 F: 5 P: 36 S: 24 T: 24 W: 2 Y: 15 V: 15
Chemical Descriptors
355
C1655H2585N477O550S18
38541.68
7.54
+2
114.74
-1.039
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin (PubMed:29424690). In vivo, induces pronounced contraction and tail twitching on zebrafish larvae, as well as death 5 hours later (PubMed:29424690). {ECO:0000269|PubMed:29424690}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Nematostella vectensis (Starlet sea anemone)
Neurotoxin
Neurotoxin (PubMed:29424690). In vivo, induces pronounced contraction and tail twitching on zebrafish larvae, as well as death 5 hours later (PubMed:29424690)..
Nematocyst expressed protein 3 (NEP-3) (NEP3)
v1g238654
sea anemone
NEP3 family
Evidence at protein level
Cleavage on pair of basic residues Disulfide bond Nematocyst Neurotoxin Reference proteome Secreted Signal Toxin
TISSUE SPECIFICITY: Nematocytes (PubMed:23151943, PubMed:29424690). In late planulae, transcripts are found throughout the ectoderm in nematocytes, with high concentration of expressing cells in the oral pole (PubMed:29424690). In primary polyps, is expressed in nematocytes in the body wall and physa ectoderm and in the upper and lower pharynx (PubMed:29424690). {ECO:0000269|PubMed:23151943, ECO:0000269|PubMed:29424690}.
Additional Detail Fields 8 fields
v1g238654
Cleavage on pair of basic residues Disulfide bond Nematocyst Neurotoxin Reference proteome Secreted Signal Toxin
Neurotoxin
Evidence at protein level
NEP3 family
Nematocyst expressed protein 3 (NEP-3) (NEP3)
TISSUE SPECIFICITY: Nematocytes (PubMed:23151943, PubMed:29424690). In late planulae, transcripts are found throughout the ectoderm in nematocytes, with high concentration of expressing cells in the oral pole (PubMed:29424690). In primary polyps, is expressed in nematocytes in the body wall and physa ectoderm and in the upper and lower pharynx (PubMed:29424690). {ECO:0000269|PubMed:23151943, ECO:0000269|PubMed:29424690}.
sea anemone