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Peptide record

TPDB72341

Neurotoxin standard
76 amino acids
Basic Information
3D PDB MODEL
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TPDB72341
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 76-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MAYIYALIFAIVVCMNTDVIQAEESQHDTLENVEYRLSCIPKGGECERMADTCCPGLQCLGCNPFNKENLGKCKCQ
Physicochemical Analysis
C360H573N97O114S12
W
C
8468.81
4.51
7
10
28
-4
17.46
-0.050
78.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4970
58.69
26
Residue Composition
number
5
A
2
R
5
N
3
D
9
C
7
E
4
Q
5
G
1
H
5
I
6
L
4
K
3
M
2
F
3
P
2
S
3
T
0
W
3
Y
4
V
Amino Acid Distribution
A: 5 R: 2 N: 5 D: 3 C: 9 E: 7 Q: 4 G: 5 H: 1 I: 5 L: 6 K: 4 M: 3 F: 2 P: 3 S: 2 T: 3 W: 0 Y: 3 V: 4
Chemical Descriptors
76
C360H573N97O114S12
8468.81
4.51
-4
17.46
-0.050
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated calcium channel (Cav) currents in DRG neurons (IC(50)=1590 nM). {ECO:0000269|PubMed:22595790}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Inhibits voltage-gated calcium channel (Cav) currents in DRG neurons (IC(50)=1590 nM)..
Omega-scoloptoxin(13)-Ssm2a (Omega-SLPTX(13)-Ssm2a) (Omega-scoloptoxin-Ssm2a) (Omega-SLPTX-Ssm2a)
other
Scoloptoxin-13 family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Scoloptoxin-13 family
Omega-scoloptoxin(13)-Ssm2a (Omega-SLPTX(13)-Ssm2a) (Omega-scoloptoxin-Ssm2a) (Omega-SLPTX-Ssm2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
other