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Peptide record

TPDB72329

Neurotoxin standard
87 amino acids
Basic Information
3D PDB MODEL
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TPDB72329
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 87-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNYLILISFALLVITGVESARDAYIAKPHNCVYECFDAFSSYCNGVCTKNGAKSGYCQILGTYGNGCWCIALPDNVPIRIPGKCHRR
Physicochemical Analysis
C425H657N115O119S9
CGI
9570.13
8.09
10
5
37
+3
3.19
0.187
87.47
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14940
156.11
29
Residue Composition
number
7
A
4
R
6
N
3
D
8
C
2
E
1
Q
8
G
2
H
8
I
6
L
4
K
1
M
3
F
4
P
5
S
3
T
1
W
6
Y
5
V
Amino Acid Distribution
A: 7 R: 4 N: 6 D: 3 C: 8 E: 2 Q: 1 G: 8 H: 2 I: 8 L: 6 K: 4 M: 1 F: 3 P: 4 S: 5 T: 3 W: 1 Y: 6 V: 5
Chemical Descriptors
87
C425H657N115O119S9
9570.13
8.09
+3
3.19
0.187
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits inactivation of Nav1.6/SCN8A (EC(50)=790 nM) and drosophila DmNav1 (EC(50)=280 nM) (PubMed:21969612, Ref.2). The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612). Has antimicrobial activity (Ref.2). {ECO:0000269|PubMed:21969612, ECO:0000269|Ref.2}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits inactivation of Nav1.6/SCN8A (EC(50)=790 nM) and drosophila DmNav1 (EC(50)=280 nM) (PubMed:21969612, Ref.2).
Sodium channel neurotoxin MeuNaTxalpha-5* (MeuNaTxalpha-5b)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Evidence at protein level
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21969612, ECO:0000305|Ref.2}.
Additional Detail Fields 7 fields
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Sodium channel neurotoxin MeuNaTxalpha-5* (MeuNaTxalpha-5b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21969612, ECO:0000305|Ref.2}.
scorpion