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Peptide record

TPDB72326

Neurotoxin standard
85 amino acids
Basic Information
3D PDB MODEL
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TPDB72326
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 85-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MTSVQSVTCCCLLWLMLSVQPITPGSPGPAQLSRERSFKFLSGGFKEIVCHRYCAKGIAKEFCNCPDKRDVVSPRIRRRKRSKAM
Physicochemical Analysis
C417H686N126O113S10
RS
9593.41
10.27
17
5
29
+11
15.66
-0.212
71.06
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
76.77
24
Residue Composition
number
4
A
9
R
1
N
2
D
7
C
3
E
3
Q
5
G
1
H
4
I
6
L
7
K
3
M
4
F
6
P
9
S
3
T
1
W
1
Y
6
V
Amino Acid Distribution
A: 4 R: 9 N: 1 D: 2 C: 7 E: 3 Q: 3 G: 5 H: 1 I: 4 L: 6 K: 7 M: 3 F: 4 P: 6 S: 9 T: 3 W: 1 Y: 1 V: 6
Chemical Descriptors
85
C417H686N126O113S10
9593.41
10.27
+11
15.66
-0.212
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Causes scratching in mice. {ECO:0000269|Ref.2}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus geographus (Geography cone) (Nubecula geographus)
Neurotoxin
Causes scratching in mice..
Scratcher peptide
cone snail
Conotoxin J superfamily
Evidence at protein level
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|Ref.2}.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at protein level
Conotoxin J superfamily
Scratcher peptide
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|Ref.2}.
cone snail