TPDB

3D PDB MODEL

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TPDB ID TPDB72324

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 1068-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MPLNKDIKKVLVIGSGPIVIGQAAEFDYSGTQACEGVKEEGVEVVLINSNPATIMTDKEVADKVYLEPLTVEFVEKVIAKERPDSLLAGMGGQTGLNLAVELYDKGILKKCGVNVIGTSIESIKEGEDRELFRNVMSRINEPVIQSEIVTDIENGKAFANKIGYPVIVRPAYTLGGTGGGIAESEEELDEILALGLQVSSIGQVLLEKSVKGWKEIEYEVMRDSRGNCVTVCNMENIDPVGIHTGDSIVVAPSQTLSDKEYQMLRSASINIINSIGIKGGCNVQFALNPNSFEYAVIEINPRVSRSSALASKATGYPIAKVAAKIALGYTLDEIKNAVTQKTYACFEPSLDYVVVKIPKWPFDKFQGADRVLGTKMMATGEIMAIGSNFEAAFLKGIRSLEIGKYSLEHKKFREFSMEELKTRVISPDDERIFALAEMLRRDYRMDKVAEITGIDKFFIKKFRWIVEEEQRLILSKIDDLDKEWLYKLKKKGFSDKGIADMLNISPEDIYKLRNIWGINPVYKMVDTCGGEFEALSPYYYSTYDVYDEVEVSKNKKVIVIGSGPIRIGQGIEFDYASVHCVKALKKLGIETIIVNNNPETVSTDFDVSDKLYFEPLTEEDVLNIVEKEKPNGIILQFGGQTAIKLAKFLKEKNIPILGTTAGQIDMAEDREKFDELLEKLQISRPKGKGIWSVEDGLEETKKLGFPVLVRPSYVLGGQGMEITHDEKELVYYLSNAFQKNKKNPILIDKYLMGREIEVDAISDGEDVLIPGIMEHLERAGVHSGDSITMYPTQNVSKDIKEKILEYTKKLALGIGIKGMINIQFIEFEGNLYVIEVNPRASRTVPYISKVSKVPIVDIATRVMLGEKLNDLGYRVGVYKEPELISVKVPVFSTQKLPRVEVCLGPEMKSTGEVLGVGKTLEEALYKGFIGANMSIKKEKGTILATINDHDKEEFLPIAKKLHSIGYKFIATSKTAELLKEEGIEVKQVRKLKEESPNIIDTIKNDEVDLVINTPTKGNDSKRDGFHIRRAAIERNLGVITSLDTLKAIVNIKSKEIKDETLHIFDLSN

FASTA

>TPDB72324|Neurotoxin|length=1068
MPLNKDIKKVLVIGSGPIVIGQAAEFDYSGTQACEGVKEEGVEVVLINSNPATIMTDKEVADKVYLEPLTVEFVEKVIAKERPDSLLAGMGGQTGLNLAVELYDKGILKKCGVNVIGTSIESIKEGEDRELFRNVMSRINEPVIQSEIVTDIENGKAFANKIGYPVIVRPAYTLGGTGGGIAESEEELDEILALGLQVSSIGQVLLEKSVKGWKEIEYEVMRDSRGNCVTVCNMENIDPVGIHTGDSIVVAPSQTLSDKEYQMLRSASINIINSIGIKGGCNVQFALNPNSFEYAVIEINPRVSRSSALASKATGYPIAKVAAKIALGYTLDEIKNAVTQKTYACFEPSLDYVVVKIPKWPFDKFQGADRVLGTKMMATGEIMAIGSNFEAAFLKGIRSLEIGKYSLEHKKFREFSMEELKTRVISPDDERIFALAEMLRRDYRMDKVAEITGIDKFFIKKFRWIVEEEQRLILSKIDDLDKEWLYKLKKKGFSDKGIADMLNISPEDIYKLRNIWGINPVYKMVDTCGGEFEALSPYYYSTYDVYDEVEVSKNKKVIVIGSGPIRIGQGIEFDYASVHCVKALKKLGIETIIVNNNPETVSTDFDVSDKLYFEPLTEEDVLNIVEKEKPNGIILQFGGQTAIKLAKFLKEKNIPILGTTAGQIDMAEDREKFDELLEKLQISRPKGKGIWSVEDGLEETKKLGFPVLVRPSYVLGGQGMEITHDEKELVYYLSNAFQKNKKNPILIDKYLMGREIEVDAISDGEDVLIPGIMEHLERAGVHSGDSITMYPTQNVSKDIKEKILEYTKKLALGIGIKGMINIQFIEFEGNLYVIEVNPRASRTVPYISKVSKVPIVDIATRVMLGEKLNDLGYRVGVYKEPELISVKVPVFSTQKLPRVEVCLGPEMKSTGEVLGVGKTLEEALYKGFIGANMSIKKEKGTILATINDHDKEEFLPIAKKLHSIGYKFIATSKTAELLKEEGIEVKQVRKLKEESPNIIDTIKNDEVDLVINTPTKGNDSKRDGFHIRRAAIERNLGVITSLDTLKAIVNIKSKEIKDETLHIFDLSN

Formula C5341H8609N1379O1608S33

Absent Amino Acids

Common Amino Acids I

Mass 118928.36

PI 5.25

Basic Residues 151

Acidic Residues 161

Hydrophobic Residues 440

Net Charge -19

Boman Index 309.84

Hydrophobicity -0.185

Aliphatic Index 100.26

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 87140

Absorbance 280nm 73.27

Polar Residues 226

number

57

A

37

R

47

N

59

D

9

C

102

E

23

Q

85

G

10

H

108

I

88

L

104

K

24

M

35

F

41

P

62

S

49

T

6

W

36

Y

86

V

Amino Acid Distribution

A: 57 R: 37 N: 47 D: 59 C: 9 E: 102 Q: 23 G: 85 H: 10 I: 108 L: 88 K: 104 M: 24 F: 35 P: 41 S: 62 T: 49 W: 6 Y: 36 V: 86

Length

1068

Formula

C5341H8609N1379O1608S33

Mass

118928.36

PI

5.25

Net Charge

-19

Boman Index

309.84

Hydrophobicity

-0.185

Evidence 1 Activity

Source & Reference

Database Source NA