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Peptide record

TPDB72320

Neurotoxin standard
80 amino acids
Basic Information
3D PDB MODEL
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TPDB72320
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 80-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
AACQLGTAASFARDKQDYPAVRSDGRQDSKDSTLDRIAKRCSEGGDFCSKNSECCDKKCQDEGEGRGVCLIVPQNVILLH
Physicochemical Analysis
C357H583N113O124S7
MW
D
8666.66
5.63
13
13
22
-1
27.29
-0.661
62.25
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1865
21.52
24
Residue Composition
number
7
A
6
R
2
N
9
D
7
C
4
E
5
Q
7
G
1
H
3
I
5
L
6
K
0
M
2
F
2
P
7
S
2
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 7 R: 6 N: 2 D: 9 C: 7 E: 4 Q: 5 G: 7 H: 1 I: 3 L: 5 K: 6 M: 0 F: 2 P: 2 S: 7 T: 2 W: 0 Y: 1 V: 4
Chemical Descriptors
80
C357H583N113O124S7
8666.66
5.63
-1
27.29
-0.661
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus bullatus (Bubble cone)
Neurotoxin Ion channel impairing toxin
Conotoxin Bu14
cone snail
Conotoxin O1 superfamily
Evidence at transcript level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Conotoxin O1 superfamily
Conotoxin Bu14
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail