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Peptide record

TPDB72318

Neurotoxin standard
86 amino acids
Basic Information
3D PDB MODEL
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TPDB72318
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 86-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSIFPIALALLLIGLEEGEAARDGYPLSKNNNCKIYCPDTDVCKDTCKNRASAPDGKCDGWNSCYCFKVPDHIPVWGDPGTKPCMT
Physicochemical Analysis
C409H634N108O125S10
Q
DCP
9384.78
4.96
10
11
29
-2
15.38
-0.287
66.98
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
15970
170.17
24
Residue Composition
number
6
A
2
R
5
N
8
D
8
C
3
E
0
Q
7
G
1
H
5
I
6
L
7
K
2
M
2
F
8
P
4
S
4
T
2
W
3
Y
3
V
Amino Acid Distribution
A: 6 R: 2 N: 5 D: 8 C: 8 E: 3 Q: 0 G: 7 H: 1 I: 5 L: 6 K: 7 M: 2 F: 2 P: 8 S: 4 T: 4 W: 2 Y: 3 V: 3
Chemical Descriptors
86
C409H634N108O125S10
9384.78
4.96
-2
15.38
-0.287
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus pachyurus (Colombian scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing..
Toxin Tpa6 (T-alpha* NaTx7.4)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Toxin Tpa6 (T-alpha* NaTx7.4)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion