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Peptide record

TPDB72314

Neurotoxin standard
79 amino acids
Basic Information
3D PDB MODEL
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TPDB72314
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 79-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKTQVLALFVLCVLFCLAESRTTLNKRNDIEKRIECKCEGDAPDLSHMTGTVYFSCKGGDGSWSKCNTYTAVADCCHQA
Physicochemical Analysis
C373H594N104O117S10
C
8728.05
6.85
11
9
28
-0
14.36
-0.110
70.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8980
102.89
27
Residue Composition
number
6
A
3
R
3
N
5
D
8
C
4
E
2
Q
5
G
2
H
2
I
7
L
6
K
2
M
3
F
1
P
5
S
7
T
1
W
2
Y
5
V
Amino Acid Distribution
A: 6 R: 3 N: 3 D: 5 C: 8 E: 4 Q: 2 G: 5 H: 2 I: 2 L: 7 K: 6 M: 2 F: 3 P: 1 S: 5 T: 7 W: 1 Y: 2 V: 5
Chemical Descriptors
79
C373H594N104O117S10
8728.05
6.85
-0
14.36
-0.110
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: In neuromuscular preparation of crustaceans, the toxin increased neurotransmitter release, causing repetitive firing of the axons. May affect sodium channels (Nav). {ECO:0000269|PubMed:2567180, ECO:0000269|PubMed:7510258}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Calliactis parasitica (Sea anemone) (Actinia parasitica)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
In neuromuscular preparation of crustaceans, the toxin increased neurotransmitter release, causing repetitive firing of the axons. May affect sodium channels (Nav)..
Delta-hormotoxin-Cpt1b (Delta-HRTX-Cpt1b) (Calitoxin) (CLX) (Calitoxin-1) (CLX-1) (Neurotoxic peptide)
sea anemone
Sea anemone sodium channel inhibitory toxin family
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family
Delta-hormotoxin-Cpt1b (Delta-HRTX-Cpt1b) (Calitoxin) (CLX) (Calitoxin-1) (CLX-1) (Neurotoxic peptide)
sea anemone