Back to search

Peptide record

TPDB72309

Neurotoxin standard
102 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72309
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 102-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKFSKLSLTLALILTQALLVVCGKINEDFMENGLESHALHDEIRKPIDTEKADAERGVLDCVVNTLGCSSDKDCCGMTPSCTLGICAPSVGGIVGGLLGRAL
Physicochemical Analysis
C459H767N125O146S10
WY
L
10693.49
4.78
11
13
40
-4
20.48
0.324
107.06
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
3.51
24
Residue Composition
number
7
A
3
R
3
N
7
D
7
C
6
E
1
Q
11
G
2
H
6
I
15
L
6
K
3
M
2
F
3
P
7
S
6
T
0
W
0
Y
7
V
Amino Acid Distribution
A: 7 R: 3 N: 3 D: 7 C: 7 E: 6 Q: 1 G: 11 H: 2 I: 6 L: 15 K: 6 M: 3 F: 2 P: 3 S: 7 T: 6 W: 0 Y: 0 V: 7
Chemical Descriptors
102
C459H767N125O146S10
10693.49
4.78
-4
20.48
0.324
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of insect, but not mammalian, voltage-gated calcium channels (Cav). {ECO:0000250|UniProtKB:P82852}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Potent inhibitor of insect, but not mammalian, voltage-gated calcium channels (Cav)..
Omega-hexatoxin-Hi2a (Omega-HXTX-Hi2a) (Omega-atracotoxin-Hi2a) (Omega-AcTx-Hi2a) (SF10 peptide)
spider
Neurotoxin 15 family, 02 (omega-actx) subfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11522785, ECO:0000305|PubMed:32398368}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 15 family, 02 (omega-actx) subfamily
Omega-hexatoxin-Hi2a (Omega-HXTX-Hi2a) (Omega-atracotoxin-Hi2a) (Omega-AcTx-Hi2a) (SF10 peptide)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:11522785, ECO:0000305|PubMed:32398368}.
spider