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Peptide record

TPDB72305

Neurotoxin standard
70 amino acids
Basic Information
3D PDB MODEL
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TPDB72305
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 70-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKILYLLFAFLFLAFLSEPGNAYKRCHKKGGHCFPKTVICLPPSSDFGKMDCRWKWKCCKKGSVNNAISI
Physicochemical Analysis
C368H569N95O88S8
Q
K
7988.63
9.85
14
3
29
+9
1.86
0.041
75.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
14355
179.69
17
Residue Composition
number
4
A
2
R
3
N
2
D
6
C
1
E
0
Q
5
G
2
H
4
I
7
L
10
K
2
M
6
F
4
P
5
S
1
T
2
W
2
Y
2
V
Amino Acid Distribution
A: 4 R: 2 N: 3 D: 2 C: 6 E: 1 Q: 0 G: 5 H: 2 I: 4 L: 7 K: 10 M: 2 F: 6 P: 4 S: 5 T: 1 W: 2 Y: 2 V: 2
Chemical Descriptors
70
C368H569N95O88S8
7988.63
9.85
+9
1.86
0.041
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity). {ECO:0000250|UniProtKB:Q9PWF3}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus helleri (Southern pacific rattlesnake) (Crotalus oreganus helleri)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor.
Myotoxin (Crotamine-4) (Toxic peptide C)
snake
Crotamine-myotoxin family
Evidence at protein level
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:694946}.
Additional Detail Fields 7 fields
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Crotamine-myotoxin family
Myotoxin (Crotamine-4) (Toxic peptide C)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:694946}.
snake