Back to search

Peptide record

TPDB72302

Neurotoxin standard
129 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72302
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 129-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MPSLCIIALFGTLTFYTLIPSIHTLKCVRCDGPMSNYDCKTTYPAAEECPSLSGGSSNYCSKKETFTSNGNLEQTRRYCNSVAAPSTACTDLKTGGKLCEYSCNTDGCNSVAGMEPTRAVYFIAILMLA
Physicochemical Analysis
C597H943N157O192S15
W
T
13872.89
6.63
11
10
46
-0
13.49
-0.014
68.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11055
79.69
53
Residue Composition
number
10
A
4
R
7
N
4
D
11
C
6
E
1
Q
9
G
1
H
6
I
11
L
6
K
4
M
4
F
7
P
13
S
14
T
0
W
7
Y
4
V
Amino Acid Distribution
A: 10 R: 4 N: 7 D: 4 C: 11 E: 6 Q: 1 G: 9 H: 1 I: 6 L: 11 K: 6 M: 4 F: 4 P: 7 S: 13 T: 14 W: 0 Y: 7 V: 4
Chemical Descriptors
129
C597H943N157O192S15
13872.89
6.63
-0
13.49
-0.014
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin that increase voltage-gated calcium channel (Cav) currents in DRG neurons by 70% and 120%, when 1 uM and 10 uM are tested, respectively. {ECO:0000269|PubMed:22595790}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Toxin that increase voltage-gated calcium channel (Cav) currents in DRG neurons by 70% and 120%, when 1 uM and 10 uM are tested, respectively..
Omega-scoloptoxin(05)-Ssm1a (Omega-SLPTX(05)-Ssm1a) (Omega-scoloptoxin-Ssm1a) (Omega-SLPTX-Ssm1a)
other
Scoloptoxin-05 family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Scoloptoxin-05 family
Omega-scoloptoxin(05)-Ssm1a (Omega-SLPTX(05)-Ssm1a) (Omega-scoloptoxin-Ssm1a) (Omega-SLPTX-Ssm1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
other