Back to search

Peptide record

TPDB72299

Neurotoxin standard
94 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB72299
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 94-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKFFLMCLIIFPIMGVLGKKNGYPLDRNGKTTECSGVNAIAPHYCNSECTKVYYAESGYCCWGACYCFGLEDDKPIGPMKDITKKYCDVQIIPS
Physicochemical Analysis
C470H720N114O133S13
CGK
10512.35
7.43
11
9
37
+1
9.33
-0.007
70.53
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16430
156.29
29
Residue Composition
number
4
A
1
R
4
N
5
D
9
C
4
E
1
Q
9
G
1
H
8
I
5
L
9
K
4
M
4
F
6
P
4
S
4
T
1
W
7
Y
4
V
Amino Acid Distribution
A: 4 R: 1 N: 4 D: 5 C: 9 E: 4 Q: 1 G: 9 H: 1 I: 8 L: 5 K: 9 M: 4 F: 4 P: 6 S: 4 T: 4 W: 1 Y: 7 V: 4
Chemical Descriptors
94
C470H720N114O133S13
10512.35
7.43
+1
9.33
-0.007
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Excitatory insect toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta judaicus (Black scorpion) (Buthotus judaicus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Excitatory insect toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Beta-insect excitatory toxin Bj-xtrIT (Bj-xtrIT) (Bjxtr-IT) (BjxtrIT)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10026198}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Beta-insect excitatory toxin Bj-xtrIT (Bj-xtrIT) (Bjxtr-IT) (BjxtrIT)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:10026198}.
scorpion