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Peptide record

TPDB72288

Neurotoxin standard
71 amino acids
Basic Information
3D PDB MODEL
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TPDB72288
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 71-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSRLFMILLVICVITLGTDASQAEDSGTEKRSWPVPDAFLKAFQSWPLTDPDLKAGFKVNSAQRVAHGYGK
Physicochemical Analysis
C353H553N93O101S3
AL
7812.02
8.79
9
7
31
+1
8.33
-0.037
85.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
159.88
16
Residue Composition
number
7
A
3
R
1
N
5
D
1
C
2
E
3
Q
5
G
1
H
3
I
7
L
5
K
2
M
4
F
4
P
6
S
4
T
2
W
1
Y
5
V
Amino Acid Distribution
A: 7 R: 3 N: 1 D: 5 C: 1 E: 2 Q: 3 G: 5 H: 1 I: 3 L: 7 K: 5 M: 2 F: 4 P: 4 S: 6 T: 4 W: 2 Y: 1 V: 5
Chemical Descriptors
71
C353H553N93O101S3
7812.02
8.79
+1
8.33
-0.037
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion channels. {ECO:0000305}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus planorbis (Planorbis cone)
Neurotoxin Ion channel impairing toxin
Probable neurotoxin with unknown target. Possibly targets ion channels..
Conotoxin Pl071
cone snail
Conotoxin NSf-1 superfamily
Evidence at protein level
Amidation Cleavage on pair of basic residues Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:26506909}.
Additional Detail Fields 7 fields
Amidation Cleavage on pair of basic residues Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Conotoxin NSf-1 superfamily
Conotoxin Pl071
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:26506909}.
cone snail