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Peptide record

TPDB72281

Neurotoxin standard
162 amino acids
Basic Information
3D PDB MODEL
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TPDB72281
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 162-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MERILLCFIVATLVAISMANPRPISIDPPCWTCYYRDSSGNCAFDAIACGGARKRVPKPISIDPPCRTCYYRDSSGNCVYDAFGCGGARKRVPKPISIDPPCRTCYYRDSSGNCVYDAFGCGGARKRVPKPISIDPPCRFCYHRDGSGNCVYDAYGCGAVRK
Physicochemical Analysis
C769H1195N225O221S19
Q
C
17737.46
8.45
24
13
56
+9
19.84
-0.233
60.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22890
129.05
49
Residue Composition
number
13
A
16
R
5
N
12
D
17
C
1
E
0
Q
15
G
1
H
12
I
3
L
7
K
2
M
5
F
16
P
12
S
4
T
1
W
11
Y
9
V
Amino Acid Distribution
A: 13 R: 16 N: 5 D: 12 C: 17 E: 1 Q: 0 G: 15 H: 1 I: 12 L: 3 K: 7 M: 2 F: 5 P: 16 S: 12 T: 4 W: 1 Y: 11 V: 9
Chemical Descriptors
162
C769H1195N225O221S19
17737.46
8.45
+9
19.84
-0.233
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: [Pi-actitoxin-Ugr1a]: Affects the ASIC3 channel (ACCN3) and produces analgesic effects. It produces a reversible inhibition effect on both the transient and the sustained current of human ASIC3 channels expressed in X.laevis oocytes. It completely blocks the transient component (IC(50)=10 uM) and partially (48%) inhibits the amplitude of the sustained component (IC(50)=1.44 uM). Using in vivo tests in mice, it reverses inflammatory and acid-induced pain. {ECO:0000269|PubMed:23801332}. FUNCTION: [U-actitoxin-Ugr1b]: Does not affect the ASIC3 channel. Does not cause lethality or paralysis of noble crayfish (A.astacus) at a dose of 1 mg/kg. {ECO:0000269|PubMed:23801332}. FUNCTION: [U-actitoxin-Ugr1c]: Does not affect the ASIC3 channel. Does not cause lethality or paralysis of noble crayfish (A.astacus) at a dose of 1 mg/kg. {ECO:0000269|PubMed:23801332}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Urticina grebelnyi (Painted anemone)
Neurotoxin Ion channel impairing toxin Proton-gated sodium channel impairing toxin
[Pi-actitoxin-Ugr1a]: Affects the ASIC3 channel (ACCN3) and produces analgesic effects. It produces a reversible inhibition effect on both the transient and the sustained current of human ASIC3 channels expressed in X.laevis oocytes.
Precursor protein UG [Cleaved into: U-actitoxin-Ugr1c (U-AITX-Ugr1c) (AnmTX Ugr 9a-3) (Ugr 9-3) U-actitoxin-Ugr1b (U-AITX-Ugr1b) (AnmTX Ugr 9a-2) (Ugr 9-2) Pi-actitoxin-Ugr1a (Pi-AITX-Ugr1a) (Pi-AnmTX Ugr 9a-1) (Ugr 9-1)]
sea anemone
Sea anemone BBH family
Evidence at protein level
3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Proton-gated sodium channel impairing toxin Secreted Signal Toxin
Additional Detail Fields 6 fields
3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Proton-gated sodium channel impairing toxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin Proton-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone BBH family
Precursor protein UG [Cleaved into: U-actitoxin-Ugr1c (U-AITX-Ugr1c) (AnmTX Ugr 9a-3) (Ugr 9-3) U-actitoxin-Ugr1b (U-AITX-Ugr1b) (AnmTX Ugr 9a-2) (Ugr 9-2) Pi-actitoxin-Ugr1a (Pi-AITX-Ugr1a) (Pi-AnmTX Ugr 9a-1) (Ugr 9-1)]
sea anemone