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Peptide record

TPDB72273

Neurotoxin standard
152 amino acids
Basic Information
3D PDB MODEL
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TPDB72273
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 152-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
FNPCPYSDDTVKMIILTEQNKKQDFYTLDTIGEHNQFNKLTAKSQVVFIVWQTGIGDAITARAGYIFLLDSGLAMLVDKYQMAPVASDIKLCNAGCYCKPTYVISVKKAIQFAWEHKCVGIRCSDPGVPTDGLSGRPHYGETLHKVRSYNGK
Physicochemical Analysis
C760H1182N200O220S9
K
16929.49
8.27
21
14
61
+3
22.55
-0.187
81.45
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
23295
137.60
45
Residue Composition
number
10
A
4
R
6
N
10
D
6
C
4
E
7
Q
12
G
4
H
11
I
10
L
13
K
3
M
6
F
7
P
8
S
10
T
2
W
8
Y
11
V
Amino Acid Distribution
A: 10 R: 4 N: 6 D: 10 C: 6 E: 4 Q: 7 G: 12 H: 4 I: 11 L: 10 K: 13 M: 3 F: 6 P: 7 S: 8 T: 10 W: 2 Y: 8 V: 11
Chemical Descriptors
152
C760H1182N200O220S9
16929.49
8.27
+3
22.55
-0.187
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin of presynaptic effect which degrades lysophospholipids. {ECO:0000269|PubMed:2742606}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Vespa orientalis (Oriental hornet)
Neurotoxin Presynaptic neurotoxin
Neurotoxin of presynaptic effect which degrades lysophospholipids..
Orientotoxin-1 (EC 3.1.1.5) (Lysophospholipase) (Orientotoxin I)
insect
Evidence at protein level
Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2742606}.
Additional Detail Fields 6 fields
Direct protein sequencing Hydrolase Lipid degradation Lipid metabolism Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Orientotoxin-1 (EC 3.1.1.5) (Lysophospholipase) (Orientotoxin I)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2742606}.
insect