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Peptide record

TPDB72263

Neurotoxin standard
79 amino acids
Basic Information
3D PDB MODEL
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TPDB72263
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 79-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSRKLLAVLMVCTFFLIAASMGTNALPFHEGIERRAAKCVDKMPFVCMRKDIPAICKNRNHRSYAFIMDVCRKTCGQCT
Physicochemical Analysis
C389H638N114O102S13
W
A
8960.83
9.59
15
5
35
+8
10.42
0.184
77.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
20.81
19
Residue Composition
number
8
A
7
R
3
N
3
D
7
C
2
E
1
Q
3
G
2
H
5
I
5
L
6
K
6
M
5
F
3
P
3
S
4
T
0
W
1
Y
5
V
Amino Acid Distribution
A: 8 R: 7 N: 3 D: 3 C: 7 E: 2 Q: 1 G: 3 H: 2 I: 5 L: 5 K: 6 M: 6 F: 5 P: 3 S: 3 T: 4 W: 0 Y: 1 V: 5
Chemical Descriptors
79
C389H638N114O102S13
8960.83
9.59
+8
10.42
0.184
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin (PubMed:33060291). In vivo, induces contraction paralysis followed by death (within 2 hours) on zebrafish larvae (PubMed:33060291). Also induces body contraction in Nematostella 11-dpf polyps (PubMed:33060291). {ECO:0000269|PubMed:33060291}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Nematostella vectensis (Starlet sea anemone)
Neurotoxin
Neurotoxin (PubMed:33060291). In vivo, induces contraction paralysis followed by death (within 2 hours) on zebrafish larvae (PubMed:33060291).
Neurotoxin ShK-like1
sea anemone
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Nematocyst Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed in nematocytes (in planulae and primary polyps). Is localized predominantly in the body column nematocytes and not in the tentacles (in primary polyps). {ECO:0000269|PubMed:33060291}.
Additional Detail Fields 6 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Nematocyst Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at protein level
Neurotoxin ShK-like1
TISSUE SPECIFICITY: Expressed in nematocytes (in planulae and primary polyps). Is localized predominantly in the body column nematocytes and not in the tentacles (in primary polyps). {ECO:0000269|PubMed:33060291}.
sea anemone