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Peptide record

TPDB72260

Neurotoxin standard
84 amino acids
Basic Information
3D PDB MODEL
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TPDB72260
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 84-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MSWMFYSFIVFTLAIKEVIAIDGLEICSNDQLHVTIYSIFSPLFDKPKLNYYFNCSCPGSIYISDVYPKYFNDIAHIEYRCKLT
Physicochemical Analysis
C463H682N102O125S6
I
9869.48
5.36
8
8
42
-2
-0.27
0.298
96.31
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
17670
179.04
28
Residue Composition
number
3
A
1
R
4
N
5
D
4
C
3
E
1
Q
2
G
2
H
11
I
6
L
5
K
2
M
7
F
4
P
8
S
3
T
1
W
8
Y
4
V
Amino Acid Distribution
A: 3 R: 1 N: 4 D: 5 C: 4 E: 3 Q: 1 G: 2 H: 2 I: 11 L: 6 K: 5 M: 2 F: 7 P: 4 S: 8 T: 3 W: 1 Y: 8 V: 4
Chemical Descriptors
84
C463H682N102O125S6
9869.48
5.36
-2
-0.27
0.298
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated potassium channel currents in DRG neurons. 200 nM of the toxin inhibits current amplitude by only 25% and even at concentrations up to 5 uM, the toxin does not inhibit all potassium currents. In vivo, insects injected with this toxin showed signs of neurotoxicity including twitching, paralysis, and body contraction. {ECO:0000269|PubMed:22595790}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits voltage-gated potassium channel currents in DRG neurons. 200 nM of the toxin inhibits current amplitude by only 25% and even at concentrations up to 5 uM, the toxin does not inhibit all potassium currents.
Kappa-scoloptoxin(11)-Ssm3a (Kappa-SLPTX(11)-Ssm3a) (Kappa-scoloptoxin-Ssm3a) (Kappa-SLPTX-Ssm3a)
other
Scoloptoxin-11 family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Scoloptoxin-11 family
Kappa-scoloptoxin(11)-Ssm3a (Kappa-SLPTX(11)-Ssm3a) (Kappa-scoloptoxin-Ssm3a) (Kappa-SLPTX-Ssm3a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22595790}.
other