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Peptide record

TPDB72255

Neurotoxin standard
80 amino acids
Basic Information
3D PDB MODEL
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TPDB72255
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 80-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MAKHLIVMFLVIMVISSLVDCAKKPFVQRVKNAASKAYNKLKGLAMQSQYGCPIISNMCEDHCRRKKMEGQCDLLDCVCS
Physicochemical Analysis
C388H647N109O108S13
TW
K
8983.85
8.90
14
6
35
+6
14.31
0.144
91.37
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
37.34
22
Residue Composition
number
6
A
3
R
3
N
4
D
7
C
2
E
4
Q
3
G
2
H
5
I
7
L
9
K
6
M
2
F
2
P
6
S
0
T
0
W
2
Y
7
V
Amino Acid Distribution
A: 6 R: 3 N: 3 D: 4 C: 7 E: 2 Q: 4 G: 3 H: 2 I: 5 L: 7 K: 9 M: 6 F: 2 P: 2 S: 6 T: 0 W: 0 Y: 2 V: 7
Chemical Descriptors
80
C388H647N109O108S13
8983.85
8.90
+6
14.31
0.144
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Dual-function toxin that acts both as an insecticidal and an antimicrobial peptide (PubMed:19966481, PubMed:30393903, PubMed:35490851). May inhibit voltage-gated potassium channels (Kv) (By similarity). This amphipathic peptide causes significant antimicrobial activity against E.coli (MIC=7 uM) but does not show any activity against S.aureus even at high concentration (PubMed:19966481, PubMed:30393903, PubMed:35490851). In vivo, causes paralysis or death to crickets (PubMed:19966481, PubMed:30393903, PubMed:35490851). {ECO:0000250|UniProtKB:Q0GY41, ECO:0000269|PubMed:19966481, ECO:0000269|PubMed:30393903, ECO:0000269|PubMed:35490851}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Liocheles australasiae (Dwarf wood scorpion)
Neurotoxin
Dual-function toxin that acts both as an insecticidal and an antimicrobial peptide (PubMed:19966481, PubMed:30393903, PubMed:35490851). May inhibit voltage-gated potassium channels (Kv) (By similarity).
Peptide LaIT2
scorpion
Long chain scorpion toxin family, Class 2 subfamily
Evidence at protein level
3D-structure Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:19966481}.
Additional Detail Fields 7 fields
3D-structure Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Neurotoxin Secreted Signal Toxin
Neurotoxin
Evidence at protein level
Long chain scorpion toxin family, Class 2 subfamily
Peptide LaIT2
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:19966481}.
scorpion