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Peptide record

TPDB72254

Neurotoxin standard
54 amino acids
Basic Information
3D PDB MODEL
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TPDB72254
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 54-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNFWVTFIRLIVVLSIVFAFQIAVAKAACVTHEDCTLLCYDTIGTCVDGKCKCM
Physicochemical Analysis
C271H429N65O72S8
P
V
6006.26
6.75
5
4
29
-0
-1.06
1.081
111.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
122.62
15
Residue Composition
number
5
A
1
R
1
N
3
D
6
C
1
E
1
Q
2
G
1
H
5
I
4
L
3
K
2
M
4
F
0
P
1
S
5
T
1
W
1
Y
7
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 3 C: 6 E: 1 Q: 1 G: 2 H: 1 I: 5 L: 4 K: 3 M: 2 F: 4 P: 0 S: 1 T: 5 W: 1 Y: 1 V: 7
Chemical Descriptors
54
C271H429N65O72S8
6006.26
6.75
-0
-1.06
1.081
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Selectively inhibits Kv7.1/KCNQ1 channel (Kd=11.69 uM) and inhibits Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3 with a very low potency. {ECO:0000269|PubMed:22511981}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Isometrus maculatus (Lesser brown scorpion) (Scorpio maculatus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Selectively inhibits Kv7.1/KCNQ1 channel (Kd=11.69 uM) and inhibits Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3 with a very low potency..
Potassium channel toxin alpha-KTx 28.1 (Toxin ImKTx104)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 28 subfamily
Evidence at protein level
3D-structure Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22511981}.
Additional Detail Fields 7 fields
3D-structure Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 28 subfamily
Potassium channel toxin alpha-KTx 28.1 (Toxin ImKTx104)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:22511981}.
scorpion