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Peptide record

TPDB72229

Neurotoxin standard
70 amino acids
Basic Information
3D PDB MODEL
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TPDB72229
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 70-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKVYCLLLVLLVGLVSQAHGKPTKRCLSVCSAEYEPVCGSDGKTYANKCHLMTEACWSPTSITLVHEGKC
Physicochemical Analysis
C332H538N88O97S9
F
L
7603.00
7.93
10
5
27
+2
10.47
0.210
90.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
10345
136.06
23
Residue Composition
number
4
A
1
R
1
N
1
D
7
C
4
E
1
Q
5
G
3
H
1
I
9
L
6
K
2
M
0
F
3
P
6
S
5
T
1
W
3
Y
7
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 1 C: 7 E: 4 Q: 1 G: 5 H: 3 I: 1 L: 9 K: 6 M: 2 F: 0 P: 3 S: 6 T: 5 W: 1 Y: 3 V: 7
Chemical Descriptors
70
C332H538N88O97S9
7603.00
7.93
+2
10.47
0.210
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as a neurotoxin by inhibiting an ion channel (By similarity). May also act as a serine protease inhibitor, since it possess the kazal serine protease inhibitor signature. {ECO:0000250}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Iotyrris olangoensis (Sea snail) (Lophiotoma olangoensis)
Neurotoxin Ion channel impairing toxin
Acts as a neurotoxin by inhibiting an ion channel (By similarity). May also act as a serine protease inhibitor, since it possess the kazal serine protease inhibitor signature..
Turripeptide Lol9.1 (Turripeptide OL11)
other
Conopeptide P-like superfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Protease inhibitor Secreted Serine protease inhibitor Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Protease inhibitor Secreted Serine protease inhibitor Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Conopeptide P-like superfamily
Turripeptide Lol9.1 (Turripeptide OL11)
TISSUE SPECIFICITY: Expressed by the venom duct.
other