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Peptide record

TPDB72228

Neurotoxin standard
82 amino acids
Basic Information
3D PDB MODEL
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TPDB72228
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 82-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MNKALFLCLVVLCAAVVFAAEDLQKAKHAPFKRGAQVCFCPGKVDRGDLWILRGDCPGGYGYTSNCYTWPNICCYPQSFSGR
Physicochemical Analysis
C406H617N109O108S9
ACG
9041.57
8.30
10
5
35
+4
1.35
0.121
73.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
17460
193.11
23
Residue Composition
number
8
A
4
R
3
N
4
D
8
C
1
E
3
Q
8
G
1
H
2
I
7
L
5
K
1
M
5
F
5
P
3
S
2
T
2
W
4
Y
6
V
Amino Acid Distribution
A: 8 R: 4 N: 3 D: 4 C: 8 E: 1 Q: 3 G: 8 H: 1 I: 2 L: 7 K: 5 M: 1 F: 5 P: 5 S: 3 T: 2 W: 2 Y: 4 V: 6
Chemical Descriptors
82
C406H617N109O108S9
9041.57
8.30
+4
1.35
0.121
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv3 voltage-gated potassium channels. Reduces blood pressure. {ECO:0000250|UniProtKB:P11494}.

Target

voltage-gated potassium channel (Kv) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia viridis (Snakelocks anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Kv3 voltage-gated potassium channels. Reduces blood pressure..
Kappa-actitoxin-Avd4j (Kappa-AITX-Avd4j) (Antihypertensive protein BDS-10) (Blood depressing substance 10) (BDS-10)
sea anemone
Sea anemone type 3 (BDS) potassium channel toxin family
Evidence at transcript level
Cleavage on pair of basic residues Disulfide bond Hypotensive agent Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Weakly expressed in the ectodermal tissue from the distal and proximal tentacles, body wall, and oral disk. {ECO:0000269|PubMed:24177670}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Disulfide bond Hypotensive agent Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at transcript level
Sea anemone type 3 (BDS) potassium channel toxin family
Kappa-actitoxin-Avd4j (Kappa-AITX-Avd4j) (Antihypertensive protein BDS-10) (Blood depressing substance 10) (BDS-10)
TISSUE SPECIFICITY: Weakly expressed in the ectodermal tissue from the distal and proximal tentacles, body wall, and oral disk. {ECO:0000269|PubMed:24177670}.
sea anemone