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Peptide record

TPDB72227

Neurotoxin standard
90 amino acids
Basic Information
3D PDB MODEL
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TPDB72227
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 90-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
QDEVGLGSCSVIFVVGNEEGEAKDGYAVGGDRCRVRCSPLGKNKDCETACRKKAGSYYGYCYLWFCYCENVSESAVVWGNPTLGPCLSDG
Physicochemical Analysis
C417H634N114O135S9
HM
G
9692.84
4.59
9
12
30
-3
16.32
-0.280
60.56
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
20440
210.88
29
Residue Composition
number
5
A
4
R
4
N
5
D
9
C
7
E
1
Q
13
G
0
H
1
I
5
L
5
K
0
M
2
F
3
P
7
S
2
T
2
W
6
Y
9
V
Amino Acid Distribution
A: 5 R: 4 N: 4 D: 5 C: 9 E: 7 Q: 1 G: 13 H: 0 I: 1 L: 5 K: 5 M: 0 F: 2 P: 3 S: 7 T: 2 W: 2 Y: 6 V: 9
Chemical Descriptors
90
C417H634N114O135S9
9692.84
4.59
-3
16.32
-0.280
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Putative sodium channel toxin. {ECO:0000305|PubMed:33181162}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus serrulatus (Brazilian yellow scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Putative sodium channel toxin..
Putative sodium channel toxin Ts35 (Tityustoxin-35)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:33181162}.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Putative sodium channel toxin Ts35 (Tityustoxin-35)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:33181162}.
scorpion