TPDB

3D PDB MODEL

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TPDB ID TPDB72226

Activity

Neurotoxin

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2

Sequence_Type

standard

Has_Modification No

Description A 246-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.

Sequence

MSGHSKWHNIQAKKGKVDAKRGKIFTKIGKEIVVAVKQGGPSADSNPRLRDVIAKAKANNMPNDTIERSIKKASGELNAVDYETITYEGYGPAGIAVLVDVLTDNKNRSAGNVRYAFTKQGGNMGSTGCVSFMFQSKGQIVIEKKDGLDEDELMMMALDAGAEDFESEDEVYAVTTSQEDFGTVREALEAEGLEFLEAEIKMVPNTYTAIDEETATKFQKMLDVLEDDDDVQNVYHNAEFPEGWEE

FASTA

>TPDB72226|Neurotoxin|length=246
MSGHSKWHNIQAKKGKVDAKRGKIFTKIGKEIVVAVKQGGPSADSNPRLRDVIAKAKANNMPNDTIERSIKKASGELNAVDYETITYEGYGPAGIAVLVDVLTDNKNRSAGNVRYAFTKQGGNMGSTGCVSFMFQSKGQIVIEKKDGLDEDELMMMALDAGAEDFESEDEVYAVTTSQEDFGTVREALEAEGLEFLEAEIKMVPNTYTAIDEETATKFQKMLDVLEDDDDVQNVYHNAEFPEGWEE

Formula C1180H1857N317O393S10

Absent Amino Acids

Common Amino Acids E

Mass 27093.21

PI 4.41

Basic Residues 31

Acidic Residues 46

Hydrophobic Residues 94

Net Charge -18

Boman Index 86.90

Hydrophobicity -0.552

Aliphatic Index 71.38

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 21430

Absorbance 280nm 79.10

Polar Residues 55

number

23

A

7

R

13

N

20

D

1

C

26

E

8

Q

21

G

3

H

13

I

12

L

21

K

9

M

9

F

6

P

12

S

14

T

2

W

7

Y

19

V

Amino Acid Distribution

A: 23 R: 7 N: 13 D: 20 C: 1 E: 26 Q: 8 G: 21 H: 3 I: 13 L: 12 K: 21 M: 9 F: 9 P: 6 S: 12 T: 14 W: 2 Y: 7 V: 19

Length

246

Formula

C1180H1857N317O393S10

Mass

27093.21

PI

4.41

Net Charge

-18

Boman Index

86.90

Hydrophobicity

-0.552

Evidence 1 Activity

Source & Reference

Database Source NA