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Peptide record

TPDB72217

Neurotoxin standard
84 amino acids
Basic Information
3D PDB MODEL
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TPDB72217
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 84-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MKIAIVMTLLLVAFSTASFAIEPIERAALDLVMARADSGGDAGGDAGADDEGSCKWMFQSCEPPAKCCDGWTCYKGRCNLILGR
Physicochemical Analysis
C384H610N104O118S10
H
A
8892.29
4.45
8
11
37
-3
9.71
0.210
80.36
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12865
144.68
17
Residue Composition
number
12
A
4
R
1
N
7
D
6
C
4
E
1
Q
9
G
0
H
5
I
7
L
4
K
4
M
3
F
3
P
5
S
3
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 12 R: 4 N: 1 D: 7 C: 6 E: 4 Q: 1 G: 9 H: 0 I: 5 L: 7 K: 4 M: 4 F: 3 P: 3 S: 5 T: 3 W: 2 Y: 1 V: 3
Chemical Descriptors
84
C384H610N104O118S10
8892.29
4.45
-3
9.71
0.210
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weakly nhibits voltage-gated sodium channels Nav1.7/SCN9A. High concentration of the toxin (3 uM) inhibits Nav1.7/SCN9A currents by 79%. {ECO:0000269|PubMed:35202167}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteropoda pingtungensis (Pingtung huntsman spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Weakly nhibits voltage-gated sodium channels Nav1.7/SCN9A. High concentration of the toxin (3 uM) inhibits Nav1.7/SCN9A currents by 79%..
Mu-Sparatoxin-Hp1 (HptTx-208)
spider
Neurotoxin 10 (Hwtx-1) family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:35202167}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family
Mu-Sparatoxin-Hp1 (HptTx-208)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:35202167}.
spider