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Peptide record

TPDB72201

Neurotoxin standard
88 amino acids
Basic Information
3D PDB MODEL
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TPDB72201
Neurotoxin
Toxicity and safety peptides
NTxPred2
standard
No
A 88-aa standard natural neurotoxin peptide sequence curated from NTxPred2, with an available 3D structural model.
Sequence
MATTMTVVLITSVLLVLAEIFPRDTDGQAAHKSTDQLSQLVDHLKLRKLSRRQYCPSNTCNERDECPGNCNDCEYVPGTGPNKRCVKK
Physicochemical Analysis
C416H687N125O133S8
W
L
9824.27
8.02
14
10
27
+2
25.90
-0.497
76.36
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
34.15
30
Residue Composition
number
4
A
6
R
5
N
6
D
6
C
4
E
4
Q
4
G
2
H
2
I
9
L
6
K
2
M
1
F
5
P
5
S
8
T
0
W
2
Y
7
V
Amino Acid Distribution
A: 4 R: 6 N: 5 D: 6 C: 6 E: 4 Q: 4 G: 4 H: 2 I: 2 L: 9 K: 6 M: 2 F: 1 P: 5 S: 5 T: 8 W: 0 Y: 2 V: 7
Chemical Descriptors
88
C416H687N125O133S8
9824.27
8.02
+2
25.90
-0.497
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as a neurotoxin by inhibiting an ion channel. {ECO:0000250}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Iotyrris olangoensis (Sea snail) (Lophiotoma olangoensis)
Neurotoxin Ion channel impairing toxin
Acts as a neurotoxin by inhibiting an ion channel..
Turripeptide Lol142 (OL142)
other
Conopeptide P-like superfamily
Evidence at transcript level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Conopeptide P-like superfamily
Turripeptide Lol142 (OL142)
TISSUE SPECIFICITY: Expressed by the venom duct.
other